PDP1

Description		pyruvate dehydrogenase phosphatase catalytic subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex
Drugs
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS
Novel Interacting Genes		1 novel interacting genes: PLEKHF2
Interacting Genes		11 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 OGT PDHA1 PRKCD SIRT3
Entrez ID		54704
HPRD ID		16185
Ensembl ID		ENSG00000164951
Uniprot IDs		Q6P1N1 Q9P0J1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ceramide Biosynthetic Process Acetyl-CoA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Salivary Gland Morphogenesis Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Lipid Metabolic Process Enzyme Binding Acetyl-CoA Metabolic Process Gland Morphogenesis Positive Regulation Of Amide Metabolic Process Regulation Of Lipid Biosynthetic Process Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metanephric Proximal Convoluted Tubule Development Epithelium Development Propionyl-CoA Biosynthetic Process Transferase Activity C-acetyltransferase Activity Positive Regulation Of Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Signaling Multivesicular Body, Internal Vesicle Lumen Regulation Of Catalytic Activity Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Protein Modification Process Regulation Of MAPK Cascade Positive Regulation Of DNA Metabolic Process Tissue Development Kidney Epithelium Development Positive Regulation Of Phosphate Metabolic Process Shc-EGFR Complex Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Regulation Of Lateral Mesodermal Cell Fate Specification Regulation Of Lipid Metabolic Process Regulation Of Amide Metabolic Process Positive Regulation Of Sphingomyelin Catabolic Process
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