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IL6R and ERAP1
Number of citations of the paper that reports this interaction (PubMedID
12748171
)
0
Data Source:
HPRD
(in vivo)
IL6R
ERAP1
Description
interleukin 6 receptor
endoplasmic reticulum aminopeptidase 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Interleukin-6 Receptor Complex
External Side Of Plasma Membrane
Membrane
Apical Plasma Membrane
Receptor Complex
Ciliary Neurotrophic Factor Receptor Complex
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Extracellular Exosome
Molecular Function
Cytokine Receptor Activity
Ciliary Neurotrophic Factor Receptor Activity
Interleukin-6 Receptor Activity
Interleukin-11 Receptor Activity
Interleukin-6 Receptor Binding
Protein Binding
Enzyme Binding
Interleukin-11 Binding
Interleukin-6 Binding
Protein Homodimerization Activity
Ciliary Neurotrophic Factor Binding
Endopeptidase Activity
Aminopeptidase Activity
Interleukin-6 Receptor Binding
Interleukin-1, Type II Receptor Binding
Protein Binding
Peptidase Activity
Metalloexopeptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Metalloaminopeptidase Activity
Biological Process
Hepatic Immune Response
Neutrophil Mediated Immunity
Monocyte Chemotaxis
Positive Regulation Of Leukocyte Chemotaxis
Acute-phase Response
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Vascular Endothelial Growth Factor Production
Cytokine-mediated Signaling Pathway
Endocrine Pancreas Development
Developmental Process
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Negative Regulation Of Collagen Biosynthetic Process
Response To Cytokine
Interleukin-11-mediated Signaling Pathway
Positive Regulation Of MAPK Cascade
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Smooth Muscle Cell Proliferation
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Interleukin-6-mediated Signaling Pathway
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Positive Regulation Of Glomerular Mesangial Cell Proliferation
T-helper 17 Cell Lineage Commitment
Extrinsic Apoptotic Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Platelet Aggregation
Angiogenesis
Adaptive Immune Response
Immune System Process
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Peptide Antigen Assembly With MHC Class I Protein Complex
Proteolysis
Membrane Protein Ectodomain Proteolysis
Regulation Of Blood Pressure
Response To Bacterium
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Peptide Catabolic Process
Regulation Of Innate Immune Response
Fat Cell Differentiation
Positive Regulation Of Angiogenesis
Pathways
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Interleukin-4 and Interleukin-13 signaling
Transcriptional regulation of granulopoiesis
Potential therapeutics for SARS
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Tocilizumab
Sarilumab
Satralizumab
Diseases
GWAS
Abdominal aortic aneurysm (
27899403
)
Acute anterior uveitis (with or without ankylosing spondylitis) (
25200001
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Ankylosing spondylitis (
23749187
)
Asthma (
32296059
21907864
)
Atopic dermatitis (
26482879
)
Atrial fibrillation (
29892015
)
Blood protein levels (
30072576
23696881
)
Blood protein levels in cardiovascular risk (
28369058
)
C-reactive protein (
19567438
18439548
)
C-reactive protein levels (
30388399
29878111
29403010
21300955
33339817
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Coronary artery disease (
26343387
32469254
29212778
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Fibrinogen (
20031577
23969696
)
Fibrinogen levels (
28107422
26561523
)
Interleukin-6 levels (
33517400
32473944
)
Interleukin-6 levels in HIV infection (
33095540
)
Iron status biomarkers (iron levels) (
33536631
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Mosquito bite size (
28199695
)
Myocardial infarction (
26343387
33532862
)
Parental longevity (combined parental attained age, Martingale residuals) (
29227965
)
Platelet count (
32888494
)
Protein quantitative trait loci (
18464913
)
Pulmonary function (
17903307
)
Red cell distribution width (
32888494
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Rheumatoid arthritis (
24390342
23143596
30423114
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Serum alkaline phosphatase levels (
33547301
)
Systemic lupus erythematosus (
28714469
)
Type 1 diabetes (
34127860
)
Acute anterior uveitis (with or without ankylosing spondylitis) (
25200001
)
Acute anterior uveitis in ankylosing spondylitis (
32492107
25200001
)
Alcohol dependence (
19581569
)
Ankylosing spondylitis (
20062062
30946743
23749187
21743469
)
Behcet's disease (
23291587
)
Birdshot chorioretinopathy (
24957906
)
Blood protein levels (
30072576
)
Body mass index (
26426971
29273807
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Colorectal cancer (
25990418
)
Emotional lability in attention deficit hyperactivity disorder (
31085060
)
Hodgkin's lymphoma (
22286212
)
Inflammatory bowel disease (
23128233
)
Inflammatory skin disease (
25574825
)
Medication use (calcium channel blockers) (
31015401
)
Psoriasis (
20953190
25854761
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Systolic blood pressure (
30578418
)
Urate levels (BMI interaction) (
25811787
)
Interacting Genes
11 interacting genes:
ADRB2
CNTF
ERAP1
IL6
IL6ST
MAGI1
SGTB
SRC
STAT3
WWP1
WWP2
4 interacting genes:
H3-4
IL6R
TNFRSF1A
WEE2-AS1
Entrez ID
3570
51752
HPRD ID
01000
06015
Ensembl ID
ENSG00000160712
ENSG00000164307
Uniprot IDs
A0A087WTB5
A0N0L5
P08887
A0A075BTL2
Q9NZ08
PDB IDs
1N26
1P9M
2ARW
5FUC
7DC8
8D82
8IOW
8QY5
8QY6
2YD0
3MDJ
3QNF
3RJO
5J5E
6M8P
6MGQ
6Q4R
6RQX
6RYF
6T6R
7MWB
7MWC
7Z28
9GJN
9GJS
9GK6
9GKE
Enriched GO Terms of Interacting Partners
?
Interleukin-6 Receptor Binding
Interleukin-6-mediated Signaling Pathway
T-helper 17 Cell Lineage Commitment
Cell Surface Receptor Signaling Pathway Via JAK-STAT
T-helper Cell Lineage Commitment
Cell Surface Receptor Signaling Pathway Via STAT
CD4-positive, Alpha-beta T Cell Lineage Commitment
Alpha-beta T Cell Lineage Commitment
CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment
Regulation Of Notch Signaling Pathway
Negative Regulation Of Primary MiRNA Processing
T Cell Lineage Commitment
Positive Regulation Of Vascular Endothelial Growth Factor Production
Interleukin-6 Receptor Complex
Cell Differentiation
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Positive Regulation Of Notch Signaling Pathway
Regulation Of Vascular Endothelial Growth Factor Production
Ciliary Neurotrophic Factor Receptor Binding
Interleukin-11-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Negative Regulation Of MiRNA Processing
Cellular Developmental Process
Retinal Rod Cell Differentiation
Positive Regulation Of Extracellular Matrix Disassembly
Intestinal Epithelial Cell Development
Inflammatory Response To Wounding
Positive Regulation Of Platelet Aggregation
Positive Regulation Of Developmental Process
Regulation Of MiRNA Processing
Developmental Process
Camera-type Eye Photoreceptor Cell Differentiation
Negative Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Regulation Of Regulatory NcRNA Processing
Protein Tyrosine Kinase Activator Activity
Columnar/cuboidal Epithelial Cell Development
Negative Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Eye Photoreceptor Cell Differentiation
Positive Regulation Of Homotypic Cell-cell Adhesion
Negative Regulation Of Anoikis
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Phosphate Metabolic Process
Photoreceptor Cell Differentiation
Symbiont Entry Into Host Cell
Positive Regulation Of Cell-cell Adhesion
Regulation Of Extracellular Matrix Disassembly
Bone Resorption
Extrinsic Apoptotic Signaling Pathway
Ciliary Neurotrophic Factor Receptor Activity
Hepatic Immune Response
Receptor Complex
Ciliary Neurotrophic Factor Binding
Interleukin-6 Receptor Complex
Interleukin-11 Receptor Activity
Interleukin-6 Binding
Interleukin-6 Receptor Activity
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Ciliary Neurotrophic Factor Receptor Complex
Interleukin-11 Binding
Negative Regulation Of Extracellular Matrix Constituent Secretion
Pulmonary Valve Development
Tumor Necrosis Factor Receptor Superfamily Complex
Spermatogonial Cell Division
Pre-mRNA 5'-splice Site Binding
Interleukin-11-mediated Signaling Pathway
Defense Response To Bacterium
Interleukin-6 Receptor Binding
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Vascular Endothelial Growth Factor Production
Positive Regulation Of Apoptotic Process Involved In Development
Regulation Of Extracellular Matrix Constituent Secretion
Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Aortic Valve Development
Tumor Necrosis Factor Binding
Semi-lunar Valve Development
DNA Replication-dependent Chromatin Assembly
MRNA 5'-splice Site Recognition
Positive Regulation Of Cell Proliferation Involved In Kidney Development
Apoptotic Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Regulation Of Glomerular Mesangial Cell Proliferation
Positive Regulation Of Platelet Aggregation
Regulation Of Cell Differentiation
Negative Regulation Of Collagen Biosynthetic Process
Cytokine-mediated Signaling Pathway
Response To Bacterium
T-helper 17 Cell Lineage Commitment
Interleukin-6-mediated Signaling Pathway
T-helper Cell Lineage Commitment
Endocrine Pancreas Development
Regulation Of Establishment Of Endothelial Barrier
Positive Regulation Of Homotypic Cell-cell Adhesion
U1 SnRNP
Regulation Of Membrane Lipid Metabolic Process
CD4-positive, Alpha-beta T Cell Lineage Commitment
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