IL6R and ERAP1

Number of citations of the paper that reports this interaction (PMID 12748171)
19

Data Source:
HPRD (in vivo)

		IL6R	ERAP1
Gene Name		interleukin 6 receptor	endoplasmic reticulum aminopeptidase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Neurotrophic Factor Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding	Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Metalloexopeptidase Activity Zinc Ion Binding
	Biological Process	Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Response To Cytokine Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis
Pathways		Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation	Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 21907864) C-reactive protein ( 19567438 18439548 21300955) Fibrinogen ( 20031577) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307)	Alcohol dependence ( 19581569) Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 23291587) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190)
Protein-Protein Interactions		10 interactors: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SRC STAT3 WWP1 WWP2	3 interactors: HIST3H3 IL6R TNFRSF1A
Entrez ID		3570	51752
HPRD ID		01000	06015
Ensembl ID		ENSG00000160712	ENSG00000164307
Uniprot IDs		A0N0L5 P08887	Q9NZ08
PDB IDs		1N26 1N2Q 1P9M 2ARW	2YD0 3MDJ 3QNF 3RJO
Enriched GO Terms of Interacting Partners?		Interleukin-6-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Protein Phosphorylation Viral Process Bone Remodeling Positive Regulation Of JAK-STAT Cascade Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of JAK-STAT Cascade Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Ossification Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Tissue Remodeling Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Modification Process Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Temperature Homeostasis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Acute Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Regulation Of Ossification Cellular Response To Cytokine Stimulus Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Bone Resorption Cell Differentiation	Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Regulation Of Interleukin-6 Production Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Bacterium Negative Regulation Of Cytokine Production Regulation Of Peptidyl-tyrosine Phosphorylation Hepatic Immune Response Apoptotic Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Activation Of Janus Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Collagen Biosynthetic Process Inflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Cytokine-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Metabolic Process Response To Bacterium Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cytokine Production Negative Regulation Of Interleukin-8 Production Interleukin-6-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Monocyte Chemotaxis Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Estradiol Stimulus Neutrophil Mediated Immunity Response To Cytokine Response To Other Organism Positive Regulation Of Protein Phosphorylation Response To Biotic Stimulus Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Positive Regulation Of Intracellular Signal Transduction Cellular Response To Estrogen Stimulus Prostaglandin Metabolic Process Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphorylation Response To Interleukin-6 Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Defense Response To Gram-negative Bacterium Negative Regulation Of Interleukin-6 Production Regulation Of Collagen Metabolic Process Apoptotic Process
Tagcloud ?		adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il21 intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper	ad5 adenovirus ag aminopeptidase augmented autoimmune basel behind chemokine endoplasmic genetically herein hpbmcs identifying inflammasome innate internalization investigating karger modulating mononuclear nlrp3 polymorphic pyrin reticulum secreted unexpectedly variants vectors
Tagcloud (Difference) ?		adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il21 intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper	ad5 adenovirus ag aminopeptidase augmented autoimmune basel behind chemokine endoplasmic genetically herein hpbmcs identifying inflammasome innate internalization investigating karger modulating mononuclear nlrp3 polymorphic pyrin reticulum secreted unexpectedly variants vectors
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