IL6R and IL6ST

Number of citations of the paper that reports this interaction (PubMedID 2788034)
0

Data Source:
HPRD (in vitro)

		IL6R	IL6ST
Description		interleukin 6 receptor	interleukin 6 cytokine family signal transducer
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Cell Body Membrane Raft Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Coreceptor Activity Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Interleukin-27 Receptor Activity Scaffold Protein Binding
	Biological Process	Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Developmental Process Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Response To Cytokine Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation T-helper 17 Cell Lineage Commitment Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Cell Differentiation Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis Potential therapeutics for SARS	Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs		Tocilizumab Sarilumab Satralizumab
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 32296059 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 30388399 29878111 29403010 21300955 33339817) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 26343387 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Interleukin-6 levels ( 33517400 32473944) Interleukin-6 levels in HIV infection ( 33095540) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387 33532862) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Platelet count ( 32888494) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Red cell distribution width ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 24390342 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Type 1 diabetes ( 34127860)
Interacting Genes		11 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SGTB SRC STAT3 WWP1 WWP2	35 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 NEDD4L OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		3570	3572
HPRD ID		01000	02824
Ensembl ID		ENSG00000160712	ENSG00000134352
Uniprot IDs		A0A087WTB5 A0N0L5 P08887	A0A0A0N0L2 A0A0A0N0L5 A0A8V8TMJ9 A0A8V8TNI4 P40189 Q17RA0
PDB IDs		1N26 1P9M 2ARW 5FUC 7DC8 8D82 8IOW 8QY5 8QY6	1BJ8 1BQU 1I1R 1P9M 1PVH 3L5H 3L5I 3L5J 7U7N 8D6A 8D74 8D7R 8D82 8D85 8DPS 8DPT 8DPU 8UPA 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Interleukin-6 Receptor Binding Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via JAK-STAT T-helper Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Notch Signaling Pathway Negative Regulation Of Primary MiRNA Processing T Cell Lineage Commitment Positive Regulation Of Vascular Endothelial Growth Factor Production Interleukin-6 Receptor Complex Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Notch Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Production Ciliary Neurotrophic Factor Receptor Binding Interleukin-11-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of MiRNA Processing Cellular Developmental Process Retinal Rod Cell Differentiation Positive Regulation Of Extracellular Matrix Disassembly Intestinal Epithelial Cell Development Inflammatory Response To Wounding Positive Regulation Of Platelet Aggregation Positive Regulation Of Developmental Process Regulation Of MiRNA Processing Developmental Process Camera-type Eye Photoreceptor Cell Differentiation Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of Regulatory NcRNA Processing Protein Tyrosine Kinase Activator Activity Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Eye Photoreceptor Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Anoikis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Photoreceptor Cell Differentiation Symbiont Entry Into Host Cell Positive Regulation Of Cell-cell Adhesion Regulation Of Extracellular Matrix Disassembly Bone Resorption	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process T-helper 17 Cell Lineage Commitment Regulation Of Cell Population Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Signal Transduction Interleukin-6-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway T-helper Cell Lineage Commitment Negative Regulation Of Apoptotic Process Interleukin-11-mediated Signaling Pathway Phosphotyrosine Residue Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Alpha-beta T Cell Lineage Commitment Positive Regulation Of Peptidyl-tyrosine Phosphorylation CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Adhesion Regulation Of MAPK Cascade Regulation Of Apoptotic Process T Cell Lineage Commitment Receptor Complex Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Ciliary Neurotrophic Factor Receptor Activity Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Cytokine Receptor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction
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