IL6R and WWP2

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		IL6R	WWP2
Gene Name		interleukin 6 receptor	WW domain containing E3 ubiquitin protein ligase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Neurotrophic Factor Receptor Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity
	Biological Process	Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Response To Cytokine Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation
Drugs
Diseases
GWAS		Asthma ( 21907864) C-reactive protein ( 19567438 18439548 21300955) Fibrinogen ( 20031577) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307)	IgE levels ( 23146381)
Protein-Protein Interactions		10 interactors: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SRC STAT3 WWP1 WWP2	53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1
Entrez ID		3570	11060
HPRD ID		01000	03812
Ensembl ID		ENSG00000160712	ENSG00000198373
Uniprot IDs		A0N0L5 P08887	B4DHF6 O00308
PDB IDs		1N26 1N2Q 1P9M 2ARW
Enriched GO Terms of Interacting Partners?		Interleukin-6-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Protein Phosphorylation Viral Process Bone Remodeling Positive Regulation Of JAK-STAT Cascade Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of JAK-STAT Cascade Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Ossification Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Tissue Remodeling Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Modification Process Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Temperature Homeostasis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Acute Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Regulation Of Ossification Cellular Response To Cytokine Stimulus Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Bone Resorption Cell Differentiation	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il21 intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper	accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Difference) ?		adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il21 intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper	accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Intersection) ?