POU2F1 and PKNOX1

Number of citations of the paper that reports this interaction (PubMedID 15138251)
61

Data Source:
BioGRID (pull down)

		POU2F1	PKNOX1
Description		POU class 2 homeobox 1	PBX/knotted 1 homeobox 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)	Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Interacting Genes		67 interacting genes: APP AR ARPC3 ARRB1 BARD1 BRCA1 CEBPE CREB1 CREM ESR1 FDXR HCFC1 HIVEP1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MLLT10 MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 POU6F2 PPIP5K2 PRKACA PRKDC PRR20B PRR20C PRR20D PRR20E RARA RELA RXRA SNAPC4 SNIP1 SNX24 SOX2 SP1 SP4 STAT5A STAT5B STOX1 TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 UBE2I VDR XRCC6 ZC3H10 ZFHX3 ZMYM6	56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3
Entrez ID		5451	5316
HPRD ID		01250	03653
Ensembl ID		ENSG00000143190	ENSG00000160199
Uniprot IDs		A0A8A2IE78 P14859	B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs		1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU	1X2N
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Nucleus Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Enzyme Binding Sequence-specific Double-stranded DNA Binding Nuclear Receptor Activity Gland Development Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Rhythmic Process Regulation Of MiRNA Transcription	Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding
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