POU2F1 and ARPC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU2F1	ARPC3
Description		POU class 2 homeobox 1	actin related protein 2/3 complex subunit 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Asthma ( 31619474 31959851) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)	Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		67 interacting genes: APP AR ARPC3 ARRB1 BARD1 BRCA1 CEBPE CREB1 CREM ESR1 FDXR HCFC1 HIVEP1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MLLT10 MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 POU6F2 PPIP5K2 PRKACA PRKDC PRR20B PRR20C PRR20D PRR20E RARA RELA RXRA SNAPC4 SNIP1 SNX24 SOX2 SP1 SP4 STAT5A STAT5B STOX1 TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 UBE2I VDR XRCC6 ZC3H10 ZFHX3 ZMYM6	31 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576
Entrez ID		5451	10094
HPRD ID		01250	09175
Ensembl ID		ENSG00000143190	ENSG00000111229
Uniprot IDs		A0A8A2IE78 P14859	O15145
PDB IDs		1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Nucleus Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Enzyme Binding Sequence-specific Double-stranded DNA Binding Nuclear Receptor Activity Gland Development Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Rhythmic Process Regulation Of MiRNA Transcription	Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break
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