XRN1 and EXOSC6

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		XRN1	EXOSC6
Description		5'-3' exoribonuclease 1	exosome component 6
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity G-quadruplex DNA Binding Telomerase RNA Binding	RNA Binding RNA Exonuclease Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide Cellular Response To Puromycin	DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)	Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		67 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF10 RNF187 SDHB SKIC2 SLC61A1 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	34 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		54464	118460
HPRD ID		10470	12107
Ensembl ID		ENSG00000114127	ENSG00000223496
Uniprot IDs		Q8IZH2	Q5RKV6
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process Exosome (RNase Complex) Catabolic Process Nuclear Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nuclear RNA Surveillance RNA Surveillance ATP Biosynthetic Process RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoside Triphosphate Biosynthetic Process ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Proton Motive Force-driven ATP Synthesis MRNA 3'-UTR Binding Purine Ribonucleotide Biosynthetic Process RNA Binding Positive Regulation Of RNA Splicing Generation Of Precursor Metabolites And Energy Ribose Phosphate Biosynthetic Process Supraspliceosomal Complex SnRNA Metabolic Process Purine Nucleotide Biosynthetic Process MRNA Binding Exon-exon Junction Complex Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Proton Motive Force-driven Mitochondrial ATP Synthesis Energy Derivation By Oxidation Of Organic Compounds RNA Processing Purine Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process MRNA Transport SnRNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of MRNA Processing RRNA Processing Ribose Phosphate Metabolic Process	Exosome (RNase Complex) RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance MRNA Metabolic Process Cytoplasmic Exosome (RNase Complex) Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) Nuclear RNA Surveillance RNA Surveillance RNA Exonuclease Activity RRNA Catabolic Process U4 SnRNA 3'-end Processing RNA Binding RNA Metabolic Process SnRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Processing Macromolecule Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing RRNA 3'-end Processing TRNA Decay MRNA 3'-UTR AU-rich Region Binding RRNA Metabolic Process SnRNA Processing Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RRNA Processing Catabolic Process Macromolecule Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Histone MRNA Catabolic Process Sno(s)RNA Metabolic Process CUT Catabolic Process Histone MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Binding Nucleolus
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