EXOSC6 and ZFP36

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		EXOSC6	ZFP36
Description		exosome component 6	ZFP36 ring finger protein
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Exosome (RNase Complex) P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule CCR4-NOT Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding RNA Exonuclease Activity	DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding Heat Shock Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein-containing Complex Binding Metal Ion Binding RNA Polymerase Binding 14-3-3 Protein Binding Protein-RNA Sequence-specific Adaptor Activity
	Biological Process	DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Response To Wounding Regulation Of Keratinocyte Proliferation Regulatory NcRNA-mediated Gene Silencing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription MiRNA-mediated Gene Silencing By Inhibition Of Translation P38MAPK Cascade Response To Starvation Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation MRNA Transport Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Polynucleotide Adenylyltransferase Activity Positive Regulation Of Intracellular MRNA Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		34 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	28 interacting genes: APP ATG16L1 CCDC85B CDK6 CXCL8 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 FHL3 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 PRMT2 RUNX1T1 SFN TNF UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		118460	7538
HPRD ID		12107	01835
Ensembl ID		ENSG00000223496	ENSG00000128016
Uniprot IDs		Q5RKV6	P26651
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8N 9G8O 9G8P	4J8S
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance MRNA Metabolic Process Cytoplasmic Exosome (RNase Complex) Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) Nuclear RNA Surveillance RNA Surveillance RNA Exonuclease Activity RRNA Catabolic Process U4 SnRNA 3'-end Processing RNA Binding RNA Metabolic Process SnRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Processing Macromolecule Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing RRNA 3'-end Processing TRNA Decay MRNA 3'-UTR AU-rich Region Binding RRNA Metabolic Process SnRNA Processing Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RRNA Processing Catabolic Process Macromolecule Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Histone MRNA Catabolic Process Sno(s)RNA Metabolic Process CUT Catabolic Process Histone MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Binding Nucleolus	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Catabolic Process Response To Cytokine RRNA Catabolic Process Response To Peptide Nucleus Response To External Biotic Stimulus Positive Regulation Of Leukocyte Migration Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Protein Kinase C Inhibitor Activity Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Gene Expression RNA Catabolic Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription Cytoplasm Nuclear RNA Surveillance Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Leukocyte Migration Positive Regulation Of Biosynthetic Process Cytosol Regulation Of Viral Life Cycle RNA Surveillance Phosphoserine Residue Binding Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Protein Sequestering Activity Regulation Of Translation
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