EXOSC6 and NDUFA13

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		EXOSC6	NDUFA13
Gene Name		exosome component 6	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleolus Cytosol	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane Mitochondrial Membrane Extracellular Vesicular Exosome
	Molecular Function	Exoribonuclease Activity Poly(A) RNA Binding	NADH Dehydrogenase Activity Protein Binding ATP Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching	Positive Regulation Of Peptidase Activity Respiratory Electron Transport Chain Negative Regulation Of Cell Growth Cellular Response To Interferon-beta Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Metabolic Process Small Molecule Metabolic Process Protein Import Into Mitochondrial Inner Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Retinoic Acid Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36	5 interactors: EXOSC6 LIG4 STAT3 UBE3A XRN1
Entrez ID		118460	51079
HPRD ID		12107	09452
Ensembl ID		ENSG00000223496
Uniprot IDs		Q5RKV6	Q9P0J0
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immunoglobulin Production Somatic Stem Cell Maintenance Viral Process Sperm Entry DNA Ligation Involved In DNA Recombination RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Stem Cell Maintenance Leukocyte Activation Involved In Immune Response B Cell Activation MRNA Catabolic Process Cellular Macromolecule Catabolic Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity RNA Catabolic Process Central Nervous System Development Intracellular Receptor Signaling Pathway DNA Recombination Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Stem Cell Development Lagging Strand Elongation Pro-B Cell Differentiation Leukocyte Mediated Immunity Adaptive Immune Response Nuclear MRNA Surveillance RNA Metabolic Process Establishment Of Integrated Proviral Latency Stem Cell Differentiation DNA Deamination Negative Regulation Of Glycolytic Process RNA Surveillance Immunoglobulin V(D)J Recombination Radial Glial Cell Differentiation Establishment Of Viral Latency Histone MRNA Catabolic Process T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair RRNA Catabolic Process Lymphoid Progenitor Cell Differentiation Lymphocyte Activation DNA Ligation Interleukin-6-mediated Signaling Pathway
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