XRN1 and AP1G2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		XRN1	AP1G2
Gene Name		5-3 exoribonuclease 1	adaptor-related protein complex 1, gamma 2 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Intermediate Filament Cytoskeleton	Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Membrane AP-1 Adaptor Complex Transport Vesicle
	Molecular Function	DNA Binding Exonuclease Activity Protein Binding Poly(A) RNA Binding	Protein Binding Protein Transporter Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Gene Expression RRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Histone MRNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Intracellular Protein Transport Viral Process Vesicle-mediated Transport
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS			Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		62 interactors: ALDOA ANGPTL6 AP1G2 ATP5G2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CD97 CENPBD1 CHD4 CTSB CTSH DCP1A DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 GLMP HEATR1 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SKIV2L2 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPAL ZFP36	12 interactors: AFTPH AP1S1 AP1S2 ATXN1L CENPK KDM1A NEDD4 PRMT6 RAB5A RABEP1 SYNRG XRN1
Entrez ID		54464	8906
HPRD ID		10470	04638
Ensembl ID		ENSG00000114127	ENSG00000213983
Uniprot IDs		Q8IZH2	O75843 Q86V28
PDB IDs			2E9G 2YMT 3ZHF 4BCX
Enriched GO Terms of Interacting Partners?		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Processing RRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Generation Of Precursor Metabolites And Energy Ribosome Biogenesis Cellular Metabolic Process Respiratory Electron Transport Chain Electron Transport Chain RNA Splicing RNA Localization RNA Export From Nucleus Gene Expression Cellular Respiration MRNA Processing Energy Derivation By Oxidation Of Organic Compounds Ribonucleoprotein Complex Biogenesis Cellular Process Nuclear MRNA Surveillance Metabolic Process Nuclear Export MRNA Transport RNA Surveillance MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process ATP Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Cellular Response To Thyroid Hormone Stimulus RNA Transport RNA Destabilization Dosage Compensation MRNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression	Protein Transport Establishment Of Protein Localization Endocytosis Protein Localization Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Defense Response To Virus By Virus Viral Process Receptor Internalization Cellular Protein Localization Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Regulation Of Primitive Erythrocyte Differentiation Development Involved In Symbiotic Interaction Intracellular Transport Positive Regulation Of Stem Cell Proliferation Receptor-mediated Endocytosis Receptor Metabolic Process Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Histone H3-R2 Methylation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Stem Cell Proliferation Receptor Internalization Involved In Canonical Wnt Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Endosome Size Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Establishment Of Localization In Cell Progesterone Receptor Signaling Pathway Chromatin Modification Regulation Of Immune System Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Nuclear MRNA Surveillance Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Biosynthetic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Glucocorticoid Receptor Signaling Pathway RNA Surveillance Cellular Localization Histone MRNA Catabolic Process Chromatin Organization Transport Positive Regulation Of Megakaryocyte Differentiation
Tagcloud ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Difference) ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Intersection) ?