XRN1 and CHD4

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		XRN1	CHD4
Gene Name		5-3 exoribonuclease 1	chromodomain helicase DNA binding protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Intermediate Filament Cytoskeleton	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein Complex
	Molecular Function	DNA Binding Exonuclease Activity Protein Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Microtubule Binding Zinc Ion Binding Nucleosomal DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Gene Expression RRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Histone MRNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Spindle Assembly
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS			Myopia (pathological) ( 23049088)
Protein-Protein Interactions		62 interactors: ALDOA ANGPTL6 AP1G2 ATP5G2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CD97 CENPBD1 CHD4 CTSB CTSH DCP1A DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 GLMP HEATR1 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SKIV2L2 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPAL ZFP36	17 interactors: ATM ATR CSNK2A1 EP300 HDAC1 HIST1H3A HIST3H3 IKZF4 MBD3L2 RBBP7 RNF8 RORC SMARCA4 SUMO1 TRIM27 TWIST1 XRN1
Entrez ID		54464	1108
HPRD ID		10470	04472
Ensembl ID		ENSG00000114127	ENSG00000111642
Uniprot IDs		Q8IZH2	B3KY63 F5GWX5 Q05CG6 Q14839
PDB IDs			1MM2 1MM3 2EE1 2L5U 2L75
Enriched GO Terms of Interacting Partners?		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Processing RRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Generation Of Precursor Metabolites And Energy Ribosome Biogenesis Cellular Metabolic Process Respiratory Electron Transport Chain Electron Transport Chain RNA Splicing RNA Localization RNA Export From Nucleus Gene Expression Cellular Respiration MRNA Processing Energy Derivation By Oxidation Of Organic Compounds Ribonucleoprotein Complex Biogenesis Cellular Process Nuclear MRNA Surveillance Metabolic Process Nuclear Export MRNA Transport RNA Surveillance MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process ATP Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Cellular Response To Thyroid Hormone Stimulus RNA Transport RNA Destabilization Dosage Compensation MRNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Cellular Response To Heat ATP-dependent Chromatin Remodeling Chromosome Organization Regulation Of Viral Transcription DNA Metabolic Process Chromatin Organization Regulation Of Gene Expression, Epigenetic Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Binding RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Regulation Of Cellular Response To Heat Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Rhythmic Process Cellular Metabolic Process Interaction With Symbiont Regulation Of Response To DNA Damage Stimulus Chromatin Modification Regulation Of RNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleosome Organization Regulation Of Viral Process Regulation Of Signal Transduction By P53 Class Mediator Histone Modification Transcription, DNA-templated Chromatin Remodeling Regulation Of Metabolic Process RNA Biosynthetic Process Response To Temperature Stimulus
Tagcloud ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2	1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt finger fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified
Tagcloud (Difference) ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2	1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt finger fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified
Tagcloud (Intersection) ?