XRN1 and NDUFB10

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		XRN1	NDUFB10
Gene Name		5-3 exoribonuclease 1	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Intermediate Filament Cytoskeleton	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Exonuclease Activity Protein Binding Poly(A) RNA Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Gene Expression RRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Histone MRNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Mitochondrial Electron Transport, NADH To Ubiquinone Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		62 interactors: ALDOA ANGPTL6 AP1G2 ATP5G2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CD97 CENPBD1 CHD4 CTSB CTSH DCP1A DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 GLMP HEATR1 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SKIV2L2 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPAL ZFP36	5 interactors: FAM9B HTR2A LIG4 UPF1 XRN1
Entrez ID		54464	4716
HPRD ID		10470	11958
Ensembl ID		ENSG00000114127	ENSG00000140990
Uniprot IDs		Q8IZH2	A8K761 O96000
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Processing RRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Generation Of Precursor Metabolites And Energy Ribosome Biogenesis Cellular Metabolic Process Respiratory Electron Transport Chain Electron Transport Chain RNA Splicing RNA Localization RNA Export From Nucleus Gene Expression Cellular Respiration MRNA Processing Energy Derivation By Oxidation Of Organic Compounds Ribonucleoprotein Complex Biogenesis Cellular Process Nuclear MRNA Surveillance Metabolic Process Nuclear Export MRNA Transport RNA Surveillance MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process ATP Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Cellular Response To Thyroid Hormone Stimulus RNA Transport RNA Destabilization Dosage Compensation MRNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression	Histone MRNA Catabolic Process Histone MRNA Metabolic Process DNA Ligation Involved In DNA Recombination Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Phospholipase C-activating Serotonin Receptor Signaling Pathway RNA Catabolic Process Positive Regulation Of Phosphatidylinositol Biosynthetic Process DNA Replication Lagging Strand Elongation Pro-B Cell Differentiation Positive Regulation Of Phospholipid Biosynthetic Process Nuclear MRNA Surveillance Artery Smooth Muscle Contraction Establishment Of Integrated Proviral Latency Tonic Smooth Muscle Contraction RNA Surveillance Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Urinary Bladder Smooth Muscle Contraction DNA Ligation Involved In DNA Repair Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination RRNA Catabolic Process Lymphoid Progenitor Cell Differentiation Dosage Compensation Positive Regulation Of Glycolytic Process Aromatic Compound Catabolic Process DNA Ligation Serotonin Receptor Signaling Pathway Vascular Smooth Muscle Contraction Behavioral Response To Cocaine Negative Regulation Of Synaptic Transmission, Glutamatergic Sleep Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion MRNA Metabolic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Protein Localization To Cytoskeleton DNA Repair Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Dopamine Secretion Negative Regulation Of Potassium Ion Transport Phosphatidylinositol 3-kinase Signaling Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Temperature Homeostasis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Tagcloud ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2	aldoa atp5a1 atp5b atp5h cox5a cox5b dlst eno1 etc fbp1 glycolysis idh2 idh3a nduf2 ndufa5 ogdh organelles oxphos pgk1 rab sdha spatio suclag2 taldo1 tca uqcrh uqrb uqrc2
Tagcloud (Difference) ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2	aldoa atp5a1 atp5b atp5h cox5a cox5b dlst eno1 etc fbp1 glycolysis idh2 idh3a nduf2 ndufa5 ogdh organelles oxphos pgk1 rab sdha spatio suclag2 taldo1 tca uqcrh uqrb uqrc2
Tagcloud (Intersection) ?