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XRN1 and SLC61A1
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
BioGRID
(two hybrid)
XRN1
SLC61A1
Description
5'-3' exoribonuclease 1
solute carrier family 61 member 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
P-body
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Plasma Membrane
Membrane
Molecular Function
G-quadruplex RNA Binding
Nucleic Acid Binding
DNA Binding
RNA Binding
Nuclease Activity
Exonuclease Activity
5'-3' RNA Exonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
Hydrolase Activity
G-quadruplex DNA Binding
Telomerase RNA Binding
Protein Binding
Molybdate Ion Transmembrane Transporter Activity
Biological Process
Nuclear-transcribed MRNA Catabolic Process
RNA Metabolic Process
RRNA Catabolic Process
Negative Regulation Of Translation
Negative Regulation Of Telomere Maintenance Via Telomerase
Response To Testosterone
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Cellular Response To Cycloheximide
Cellular Response To Puromycin
Monoatomic Ion Transport
Molybdate Ion Transport
Response To Food
Response To Starvation
Pathways
mRNA decay by 5' to 3' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS
Benign childhood epilepsy with centro-temporal spikes (
32580138
)
Birth weight (
31043758
)
Caffeine consumption from coffee or tea (
33287642
)
Heel bone mineral density (
30598549
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) (
33987465
)
Waist-hip ratio (
28552196
)
Interacting Genes
67 interacting genes:
ADGRE5
ALDOA
ANGPTL6
AP1G2
ATP5MC2
B3GALT6
BAG6
C1GALT1
CBX5
CCT5
CENPBD1P
CHD4
CTSB
CTSH
DCP1B
DNASE2
DPP7
DXO
EXOSC1
EXOSC10
EXOSC6
EXOSC8
FADS1
FBXO7
GLMP
HEATR1
HERC2P4
HNRNPA1
KATNB1
LDHA
LEPR
LGALS3BP
LINC01541
LSM4
MAN2C1
MIR34C
MIR429
MIR7-1
MTCH2
MTREX
NDUFA13
NDUFB10
NDUFB9
PABPC4
PLEKHG2
POLD2
PPP2CA
PRADC1
PSMB5
RBMX
RNF10
RNF187
SDHB
SKIC2
SLC61A1
SMARCD2
SNHG1
SPATA20
SRRM2
STAM2
TMEM50A
UPF1
UPF2
UPF3B
VWA5B2
WAPL
ZFP36
58 interacting genes:
ADGRE2
AQP6
ARL6IP1
BEST2
BLCAP
BTNL9
C2CD2L
CBARP
CCL4L2
CD40
CD79A
CLDN7
CLRN1
CREB3
CREB3L1
ERRFI1
FFAR2
FXYD3
GJA5
GLP1R
GOSR2
GPR101
GPR152
GPR25
GPR42
GPX8
HSD17B13
IGFBP5
IL27RA
KASH5
LAT
LHFPL5
LMNA
MMGT1
MUC1
PEX19
PKMYT1
PLN
RNF144A
RNF19B
RTP2
SCN3B
SHISAL1
SLC10A6
SLC18A2
SLC39A9
SSMEM1
STATH
TBXA2R
TIMMDC1
TMEM128
TMEM130
TMEM14B
TMEM179B
TMEM203
TMEM237
XRN1
YIPF6
Entrez ID
54464
84975
HPRD ID
10470
14416
Ensembl ID
ENSG00000114127
ENSG00000182544
Uniprot IDs
Q8IZH2
Q6N075
PDB IDs
Enriched GO Terms of Interacting Partners
?
Nucleobase-containing Compound Catabolic Process
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
Macromolecule Catabolic Process
Exosome (RNase Complex)
Catabolic Process
Nuclear Exosome (RNase Complex)
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
MRNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleolar Exosome (RNase Complex)
Nuclear MRNA Surveillance
Cytoplasmic Exosome (RNase Complex)
RNA Exonuclease Activity
Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Nuclear RNA Surveillance
RNA Surveillance
ATP Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Gene Expression
Nucleoside Triphosphate Biosynthetic Process
ATP Metabolic Process
Positive Regulation Of MRNA Splicing, Via Spliceosome
Nucleic Acid Metabolic Process
Proton Motive Force-driven ATP Synthesis
MRNA 3'-UTR Binding
Purine Ribonucleotide Biosynthetic Process
RNA Binding
Positive Regulation Of RNA Splicing
Generation Of Precursor Metabolites And Energy
Ribose Phosphate Biosynthetic Process
Supraspliceosomal Complex
SnRNA Metabolic Process
Purine Nucleotide Biosynthetic Process
MRNA Binding
Exon-exon Junction Complex
Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of Metabolic Process
Proton Motive Force-driven Mitochondrial ATP Synthesis
Energy Derivation By Oxidation Of Organic Compounds
RNA Processing
Purine Ribonucleotide Metabolic Process
Nucleotide Biosynthetic Process
MRNA Transport
SnRNA Catabolic Process
Ribonucleotide Metabolic Process
Regulation Of MRNA Processing
RRNA Processing
Ribose Phosphate Metabolic Process
Membrane
Plasma Membrane
G Protein-coupled Receptor Activity
Protein Binding
Monoatomic Ion Transport
SA Node Cell Action Potential
Regulation Of Muscle System Process
Endoplasmic Reticulum Membrane
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
G Protein-coupled Receptor Signaling Pathway
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Negative Regulation Of Muscle Hypertrophy
Localization Within Membrane
Response To Testosterone
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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