EXOSC6 and MOCS3

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		EXOSC6	MOCS3
Gene Name		exosome component 6	molybdenum cofactor synthesis 3
Image
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleolus Cytosol	Cytosol
	Molecular Function	Exoribonuclease Activity Poly(A) RNA Binding	Thiosulfate Sulfurtransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity Protein Adenylyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Protein Adenylylation Enzyme Active Site Formation Via L-cysteine Persulfide Molybdopterin Cofactor Biosynthetic Process Protein Urmylation TRNA Thio-modification Small Molecule Metabolic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36	3 interactors: EXOSC6 MOCS2 XRN2
Entrez ID		118460	27304
HPRD ID		12107	10092
Ensembl ID		ENSG00000223496	ENSG00000124217
Uniprot IDs		Q5RKV6	O95396
PDB IDs		2NN6	3I2V
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	RNA Catabolic Process DNA Deamination Aromatic Compound Catabolic Process MRNA Metabolic Process Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response DNA Metabolic Process B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immunoglobulin Production Heterocycle Metabolic Process DNA-templated Transcription, Termination Water-soluble Vitamin Metabolic Process DNA Modification Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis Vitamin Metabolic Process RRNA Processing Catabolic Process RRNA Metabolic Process DNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Cell Growth Coenzyme Biosynthetic Process Leukocyte Activation Involved In Immune Response B Cell Activation MRNA Catabolic Process
Tagcloud ?			1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs2 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine
Tagcloud (Difference) ?			1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs2 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine
Tagcloud (Intersection) ?