EXOSC6 and MRPS18B

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		EXOSC6	MRPS18B
Gene Name		exosome component 6	mitochondrial ribosomal protein S18B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleolus Cytosol	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Cell Junction
	Molecular Function	Exoribonuclease Activity Poly(A) RNA Binding	Structural Constituent Of Ribosome
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching	Translation Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36	3 interactors: EWSR1 EXOSC6 RB1
Entrez ID		118460	28973
HPRD ID		12107	14781
Ensembl ID		ENSG00000223496	ENSG00000204568
Uniprot IDs		Q5RKV6	B0S7P4 Q9Y676
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process DNA Deamination Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Macrophage Differentiation Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation Positive Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Cohesion Hepatocyte Apoptotic Process RNA Metabolic Process Immune System Development Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching Mitotic Metaphase Plate Congression Protein Localization To Chromosome Neuron Maturation Sister Chromatid Cohesion Metaphase Plate Congression Negative Regulation Of Smoothened Signaling Pathway Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Establishment Of Chromosome Localization Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Myoblast Differentiation Regulation Of Mitotic Sister Chromatid Separation B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Microtubule Anchoring Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Kinase Activity Skeletal Muscle Cell Differentiation
Tagcloud ?			6b adenosyltransferase annotation bred cardiogenesis dnajb6b enriching exhibiting facile fifteen homozygosity hsp40 impose insertional larval mat2aa mutagenesis probing recessive screens shall streamlines subfamily transparency transposon uncovered vertebrate vertebrates
Tagcloud (Difference) ?			6b adenosyltransferase annotation bred cardiogenesis dnajb6b enriching exhibiting facile fifteen homozygosity hsp40 impose insertional larval mat2aa mutagenesis probing recessive screens shall streamlines subfamily transparency transposon uncovered vertebrate vertebrates
Tagcloud (Intersection) ?