XRN1 and CTSH

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		XRN1	CTSH
Gene Name		5-3 exoribonuclease 1	cathepsin H
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Intermediate Filament Cytoskeleton	Outer Dense Fiber Acrosomal Vesicle Extracellular Space Lysosome Cytosol Extracellular Vesicular Exosome Alveolar Lamellar Body
	Molecular Function	DNA Binding Exonuclease Activity Protein Binding Poly(A) RNA Binding	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Kininogen Binding Protein Complex Binding Protein Self-association Thyroid Hormone Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Gene Expression RRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Histone MRNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of Angiogenesis Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS			Bipolar disorder ( 21771265) Type 1 diabetes ( 19430480 18978792)
Protein-Protein Interactions		62 interactors: ALDOA ANGPTL6 AP1G2 ATP5G2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CD97 CENPBD1 CHD4 CTSB CTSH DCP1A DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 GLMP HEATR1 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SKIV2L2 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPAL ZFP36	5 interactors: BGLAP CSTA CSTB SFTPB XRN1
Entrez ID		54464	1512
HPRD ID		10470	00288
Ensembl ID		ENSG00000114127
Uniprot IDs		Q8IZH2	P09668
PDB IDs			1BZN
Enriched GO Terms of Interacting Partners?		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Processing RRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Generation Of Precursor Metabolites And Energy Ribosome Biogenesis Cellular Metabolic Process Respiratory Electron Transport Chain Electron Transport Chain RNA Splicing RNA Localization RNA Export From Nucleus Gene Expression Cellular Respiration MRNA Processing Energy Derivation By Oxidation Of Organic Compounds Ribonucleoprotein Complex Biogenesis Cellular Process Nuclear MRNA Surveillance Metabolic Process Nuclear Export MRNA Transport RNA Surveillance MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process ATP Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Cellular Response To Thyroid Hormone Stimulus RNA Transport RNA Destabilization Dosage Compensation MRNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression	Response To Vitamin K Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Nuclear MRNA Surveillance Response To Hydroxyisoflavone RNA Surveillance Histone MRNA Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing RRNA Catabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Response To Gravity Cellular Response To Vitamin D Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Osteoblast Development Response To Vitamin D Regulation Of Proteolysis Regulation Of Bone Resorption Response To Testosterone Cellular Response To Nutrient Regulation Of Bone Remodeling Peptide Cross-linking Negative Regulation Of Catalytic Activity Response To Zinc Ion Bone Mineralization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Cellular Protein Metabolic Process Response To Activity Respiratory Gaseous Exchange
Tagcloud ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2	17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 tnfsf13b tnfsf25 vsv
Tagcloud (Difference) ?		alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2	17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 tnfsf13b tnfsf25 vsv
Tagcloud (Intersection) ?