EXOSC6 and RAB3GAP2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		EXOSC6	RAB3GAP2
Gene Name		exosome component 6	RAB3 GTPase activating protein subunit 2 (non-catalytic)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleolus Cytosol	Cytoplasm Plasma Membrane Protein Complex
	Molecular Function	Exoribonuclease Activity Poly(A) RNA Binding	GTPase Activator Activity Enzyme Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Enzyme Regulator Activity Protein Heterodimerization Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching	Intracellular Protein Transport Positive Regulation Of Rab GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36	3 interactors: EXOSC6 FEZ1 RAB3GAP1
Entrez ID		118460	25782
HPRD ID		12107	11471
Ensembl ID		ENSG00000223496	ENSG00000118873
Uniprot IDs		Q5RKV6	Q9H2M9
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Glutamate Secretion DNA Deamination Positive Regulation Of Amino Acid Transport Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Glutamate Secretion Negative Regulation Of Macroautophagy Lipid Particle Organization Establishment Of Mitochondrion Localization Positive Regulation Of Neurotransmitter Secretion Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Hypothalamus Development Isotype Switching Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Negative Regulation Of Autophagy Somatic Recombination Of Immunoglobulin Gene Segments Mitochondrion Localization Face Morphogenesis Somatic Diversification Of Immunoglobulins Head Morphogenesis Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response System Development B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Face Development Regulation Of Neuronal Synaptic Plasticity Body Morphogenesis Immunoglobulin Production Multicellular Organismal Development Regulation Of Neurotransmitter Secretion Anatomical Structure Development Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential DNA Modification Diencephalon Development Limbic System Development Developmental Process Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Dendrite Development
Tagcloud ?			acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle
Tagcloud (Difference) ?			acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle
Tagcloud (Intersection) ?