EXOSC6 and SKIV2L2

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid)

		EXOSC6	SKIV2L2
Gene Name		exosome component 6	superkiller viralicidic activity 2-like 2 (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleolus Cytosol	Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Catalytic Step 2 Spliceosome
	Molecular Function	Exoribonuclease Activity Poly(A) RNA Binding	Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36	14 interactors: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPHOSPH6 MPP6 PBX2 SP1 UPF2 XRN1
Entrez ID		118460	23517
HPRD ID		12107	13777
Ensembl ID		ENSG00000223496	ENSG00000039123
Uniprot IDs		Q5RKV6	P42285 Q3MHC9
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis NcRNA Metabolic Process Ribonucleoprotein Complex Biogenesis Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Metabolic Process RNA Metabolic Process Nuclear MRNA Surveillance Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Gene Expression DNA Deamination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Cellular Metabolic Process Histone MRNA Catabolic Process DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process Positive Regulation Of Growth Metabolic Process Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Cell Growth Negative Regulation Of Nodal Signaling Pathway Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process
Tagcloud ?			accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages
Tagcloud (Difference) ?			accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages
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