XRN1 and DXO

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRN1	DXO
Description		5'-3' exoribonuclease 1	decapping exoribonuclease
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity G-quadruplex DNA Binding Telomerase RNA Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity MRNA 5'-diphosphatase Activity Metal Ion Binding RNA NAD+-cap (NAD+-forming) Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide Cellular Response To Puromycin	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Metabolic Process NAD-cap Decapping
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Nuclear RNA decay
Drugs
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		67 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF10 RNF187 SDHB SKIC2 SLC61A1 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	8 interacting genes: EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2
Entrez ID		54464	1797
HPRD ID		10470	16186
Ensembl ID		ENSG00000114127	ENSG00000204348
Uniprot IDs		Q8IZH2	A0A024RCW8 A0A1U9X7N5 F8WC68 O77932
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process Exosome (RNase Complex) Catabolic Process Nuclear Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nuclear RNA Surveillance RNA Surveillance ATP Biosynthetic Process RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoside Triphosphate Biosynthetic Process ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Proton Motive Force-driven ATP Synthesis MRNA 3'-UTR Binding Purine Ribonucleotide Biosynthetic Process RNA Binding Positive Regulation Of RNA Splicing Generation Of Precursor Metabolites And Energy Ribose Phosphate Biosynthetic Process Supraspliceosomal Complex SnRNA Metabolic Process Purine Nucleotide Biosynthetic Process MRNA Binding Exon-exon Junction Complex Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Proton Motive Force-driven Mitochondrial ATP Synthesis Energy Derivation By Oxidation Of Organic Compounds RNA Processing Purine Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process MRNA Transport SnRNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of MRNA Processing RRNA Processing Ribose Phosphate Metabolic Process	Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance MRNA Catabolic Process Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Nuclear RNA Surveillance Negative Regulation Of Gene Expression RNA Surveillance Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Metabolic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear Exosome (RNase Complex) RRNA Catabolic Process RRNA Metabolic Process Exosome (RNase Complex) Negative Regulation Of Metabolic Process MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Exonuclease Activity Nucleolus SnRNA Metabolic Process RRNA Processing Macromolecule Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Regulation Of Gene Expression RNA 3'-end Processing Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process RRNA 3'-end Processing 5'-3' Exonuclease Activity TRNA Decay RNA Metabolic Process Regulation Of Telomere Maintenance Nuclease Activity RNA Binding Regulation Of Macromolecule Metabolic Process Sno(s)RNA Metabolic Process
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