RIN2 and RAB5B

Number of citations of the paper that reports this interaction (PMID 11733506)
22

Data Source:
HPRD (in vitro, two hybrid)

		RIN2	RAB5B
Gene Name		Ras and Rab interactor 2	RAB5B, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm	Intracellular Endosome Early Endosome Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Small GTPase Regulator Activity GTPase Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding
	Biological Process	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Rab GTPase Activity Regulation Of Catalytic Activity	Intracellular Protein Transport Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport
Pathways
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312) Obesity-related traits ( 23251661)	Polycystic ovary syndrome ( 22885925) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Protein-Protein Interactions		7 interactors: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C	15 interactors: APOA5 CDK1 CHM EEA1 RAB7A RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		54453	5869
HPRD ID		15249	01544
Ensembl ID		ENSG00000132669	ENSG00000111540
Uniprot IDs		A1A4T0 Q8WYP3	P61020
PDB IDs			2HEI
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Ras Protein Signal Transduction Negative Regulation Of Immature T Cell Proliferation In Thymus Rab Protein Signal Transduction Intracellular Signal Transduction Plasma Membrane To Endosome Transport Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Negative Regulation Of T Cell Differentiation In Thymus Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Hydrolase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Alkanesulfonate Metabolic Process Cellular Protein Localization Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Cycle Arrest Regulation Of Smooth Muscle Cell Proliferation Vesicle-mediated Transport Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Establishment Of Protein Localization Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Regulation Of T Cell Differentiation Lipid Tube Assembly Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of T Cell Proliferation Cytoplasmic Transport Positive Regulation Of Epithelial Cell Proliferation Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Senescence-associated Heterochromatin Focus Assembly Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation	Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Vesicle-mediated Transport Endocytosis Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Endosomal Transport Regulation Of Ras GTPase Activity Organelle Fusion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Transport Early Endosome To Late Endosome Transport Membrane Organization Regulation Of Signaling Cellular Localization Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Vesicle Fusion Protein Localization Regulation Of Signal Transduction Establishment Of Localization In Cell Synaptic Vesicle To Endosome Fusion Pronuclear Fusion Epidermal Growth Factor Catabolic Process Retrograde Transport, Endosome To Golgi Nuclear Envelope Organization Organ Regeneration Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Intracellular Transport Nuclear Matrix Organization Negative Regulation Of Synaptic Plasticity Nuclear Matrix Anchoring At Nuclear Membrane Nucleus Organization Phagosome-lysosome Fusion Nuclear Migration Along Microfilament Regulation Of Metabolic Process Membrane Fusion Phagosome Acidification Protein Localization To Organelle Regulation Of Schwann Cell Differentiation Protein Geranylgeranylation Protein To Membrane Docking
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