RIN2 and RAB5C

Number of citations of the paper that reports this interaction (PMID 12972505)
26

Data Source:
HPRD (two hybrid)

		RIN2	RAB5C
Gene Name		Ras and Rab interactor 2	RAB5C, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm	Lysosomal Membrane Early Endosome Lipid Particle Plasma Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Small GTPase Regulator Activity GTPase Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Rab GTPase Activity Regulation Of Catalytic Activity	Intracellular Protein Transport Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C	10 interactors: APP APPL2 EEA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17
Entrez ID		54453	5878
HPRD ID		15249	04947
Ensembl ID		ENSG00000132669	ENSG00000108774
Uniprot IDs		A1A4T0 Q8WYP3	P51148
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Ras Protein Signal Transduction Negative Regulation Of Immature T Cell Proliferation In Thymus Rab Protein Signal Transduction Intracellular Signal Transduction Plasma Membrane To Endosome Transport Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Negative Regulation Of T Cell Differentiation In Thymus Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Hydrolase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Alkanesulfonate Metabolic Process Cellular Protein Localization Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Cycle Arrest Regulation Of Smooth Muscle Cell Proliferation Vesicle-mediated Transport Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Establishment Of Protein Localization Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Regulation Of T Cell Differentiation Lipid Tube Assembly Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of T Cell Proliferation Cytoplasmic Transport Positive Regulation Of Epithelial Cell Proliferation Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Senescence-associated Heterochromatin Focus Assembly Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation	Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Ras GTPase Activity Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of GTPase Activity Regulation Of Signal Transduction Regulation Of Signaling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Endosomal Transport Endocytosis Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Regulation Of Intracellular Signal Transduction Mating Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Regulation Of ERBB Signaling Pathway Synaptic Vesicle To Endosome Fusion Feeding Behavior Cholesterol Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Receptor Activity Sterol Metabolic Process Neuromuscular Process Intracellular Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Transition Metal Ion Homeostasis Transport Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Peptidyl-tyrosine Phosphorylation Axon Choice Point Recognition Plasma Membrane To Endosome Transport Locomotory Behavior Establishment Of Localization In Cell
Tagcloud ?			cdc42 compartment coordinately cytomegalovirus ectopic encode golgi hcmv herpesviruses infectious micrornas mirna mirnas mirs morphogenesis noninfectious rab11a reorganization resemble secretory sirnas snap23 stacks ul112 uncovered us5 vac vamp3 virion
Tagcloud (Difference) ?			cdc42 compartment coordinately cytomegalovirus ectopic encode golgi hcmv herpesviruses infectious micrornas mirna mirnas mirs morphogenesis noninfectious rab11a reorganization resemble secretory sirnas snap23 stacks ul112 uncovered us5 vac vamp3 virion
Tagcloud (Intersection) ?