RIN2

Gene Name		Ras and Rab interactor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm
	Molecular Function	Small GTPase Regulator Activity GTPase Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Rab GTPase Activity Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312) Obesity-related traits ( 23251661)
Protein-protein Interactions		7 interactors: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C
Entrez ID		54453
HPRD ID		15249
Ensembl ID		ENSG00000132669
Uniprot IDs		A1A4T0 Q8WYP3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Ras Protein Signal Transduction Negative Regulation Of Immature T Cell Proliferation In Thymus Rab Protein Signal Transduction Intracellular Signal Transduction Plasma Membrane To Endosome Transport Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Negative Regulation Of T Cell Differentiation In Thymus Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Hydrolase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Alkanesulfonate Metabolic Process Cellular Protein Localization Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Cycle Arrest Regulation Of Smooth Muscle Cell Proliferation Vesicle-mediated Transport Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Establishment Of Protein Localization Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Regulation Of T Cell Differentiation Lipid Tube Assembly Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of T Cell Proliferation Cytoplasmic Transport Positive Regulation Of Epithelial Cell Proliferation Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Senescence-associated Heterochromatin Focus Assembly Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation
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