RIN2 and RAB5A

Number of citations of the paper that reports this interaction (PubMedID 12972505)
0

Data Source:
HPRD (two hybrid)

		RIN2	RAB5A
Description		Ras and Rab interactor 2	RAB5A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Endocytic Vesicle	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity GTPase Regulator Activity Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding
	Biological Process	Endocytosis Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Vesicle-mediated Transport Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways		RAB GEFs exchange GTP for GDP on RABs	Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production
Drugs			L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases		Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
GWAS		Bipolar disorder and schizophrenia ( 20889312) Bone mineral density (total hip) ( 29883787) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol ( 31170924) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Platelet distribution width ( 27863252 32888494) Response to valproic acid in genetic generalized epilepsy ( 32308125) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398) Verbal declarative memory ( 25648963) Weight ( 28552196)	Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		7 interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C	37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1
Entrez ID		54453	5868
HPRD ID		15249	01542
Ensembl ID		ENSG00000132669	ENSG00000144566
Uniprot IDs		A1A4T0 Q8WYP3	P20339
PDB IDs			1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Plasma Membrane To Endosome Transport Endosome Early Endosome Membrane Regulation Of Cellular Component Organization Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation G Protein Activity Cellular Localization GDP Binding ERBB2-EGFR Signaling Pathway Early Endosome Negative Regulation Of T Cell Differentiation In Thymus Melanosome Regulation Of Immature T Cell Proliferation In Thymus Endocytosis Regulation Of Vesicle-mediated Transport ERBB2 Signaling Pathway Regulation Of T Cell Differentiation In Thymus Import Into Cell Regulation Of Transport Endomembrane System Endosomal Transport Cellular Response To Epidermal Growth Factor Stimulus Endosome Membrane Regulation Of Endocytosis Negative Regulation Of T Cell Differentiation Nucleotide Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Intracellular Protein Localization GTPase Activity Axon Terminus Negative Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane GTP Binding Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Clathrin-coated Endocytic Vesicle Membrane Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of T Cell Proliferation Regulation Of Protein Phosphorylation Ligase Inhibitor Activity Regulation Of Cell Growth ERBB Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Endosome Organization Regulation Of Phosphorylation	GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection
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