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RIN2 and BIN1
Number of citations of the paper that reports this interaction (PMID
12972505
)
26
Data Source:
HPRD
(in vitro)
RIN2
BIN1
Gene Name
Ras and Rab interactor 2
bridging integrator 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Cytoplasm
Nucleus
Cytoplasm
Synaptic Vesicle
Actin Cytoskeleton
Membrane
Z Disc
T-tubule
Axon
I Band
Node Of Ranvier
Axon Initial Segment
Varicosity
Axon Terminus
Cerebellar Mossy Fiber
Lipid Tube
Molecular Function
Small GTPase Regulator Activity
GTPase Activator Activity
Rab Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Complex Binding
Identical Protein Binding
Protein Heterodimerization Activity
Tau Protein Binding
GTPase Binding
RNA Polymerase Binding
Biological Process
Endocytosis
Small GTPase Mediated Signal Transduction
Positive Regulation Of Rab GTPase Activity
Regulation Of Catalytic Activity
Endocytosis
Cell Proliferation
Viral Process
Muscle Cell Differentiation
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Regulation Of Neuron Differentiation
Positive Regulation Of Endocytosis
Positive Regulation Of Astrocyte Differentiation
Lipid Tube Assembly
Regulation Of Cell Cycle Arrest
Pathways
Drugs
Diseases
GWAS
Bipolar disorder and schizophrenia (
20889312
)
Obesity-related traits (
23251661
)
Alzheimer's disease (
22832961
21460840
21627779
22005930
)
Alzheimer's disease (late onset) (
21460841
21390209
)
Protein-Protein Interactions
7 interactors:
BIN1
CDKN2A
EGFR
ERBB2
RAB5A
RAB5B
RAB5C
36 interactors:
ABL1
AMPH
AP2A1
AP2A2
APP
ASAP2
ATXN2
CUX1
DLGAP4
DNM1
DNM2
FBP1
ITGA1
ITGA3
ITGA6
MAP4K3
MBNL1
MYC
PLD1
PLD2
PTK2
RAP1A
RFX3
RIN2
RIN3
SH3GL2
SH3GLB1
SNX4
SOS1
SOS2
SYN1
SYNJ1
TP73
UBC
XRCC4
ZBTB3
Entrez ID
54453
274
HPRD ID
15249
03150
Ensembl ID
ENSG00000132669
ENSG00000136717
Uniprot IDs
A1A4T0
Q8WYP3
B7Z6Y2
O00499
Q9BTH3
PDB IDs
1MUZ
1MV0
1MV3
2FIC
2RMY
2RND
Enriched GO Terms of Interacting Partners
?
Regulation Of Endocytosis
Ras Protein Signal Transduction
Negative Regulation Of Immature T Cell Proliferation In Thymus
Rab Protein Signal Transduction
Intracellular Signal Transduction
Plasma Membrane To Endosome Transport
Regulation Of Cellular Component Organization
Regulation Of Vesicle-mediated Transport
Negative Regulation Of T Cell Differentiation In Thymus
Small GTPase Mediated Signal Transduction
Endosomal Transport
Regulation Of T Cell Differentiation In Thymus
Negative Regulation Of T Cell Differentiation
Negative Regulation Of Lymphocyte Differentiation
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Alkanesulfonate Metabolic Process
Cellular Protein Localization
Negative Regulation Of T Cell Activation
Negative Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Cell Cycle Arrest
Regulation Of Smooth Muscle Cell Proliferation
Vesicle-mediated Transport
Negative Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Establishment Of Protein Localization
Regulation Of Cell Proliferation
Positive Regulation Of Catalytic Activity
Regulation Of T Cell Differentiation
Lipid Tube Assembly
Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Astrocyte Activation
Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Lymphocyte Activation
Negative Regulation Of Cell-cell Adhesion
Signal Transduction
Phosphatidylinositol-mediated Signaling
Regulation Of T Cell Proliferation
Cytoplasmic Transport
Positive Regulation Of Epithelial Cell Proliferation
Receptor Internalization Involved In Canonical Wnt Signaling Pathway
Regulation Of Endosome Size
Senescence-associated Heterochromatin Focus Assembly
Regulation Of Lymphocyte Differentiation
Negative Regulation Of Leukocyte Activation
Regulation Of Signaling
Endocytosis
Generation Of Neurons
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Cell Projection Organization
Regulation Of ERBB Signaling Pathway
Neurogenesis
Neuron Projection Morphogenesis
Cell Projection Morphogenesis
Cell Part Morphogenesis
Regulation Of Signal Transduction
Axon Guidance
Neuron Differentiation
Neuron Development
Nervous System Development
Vesicle-mediated Transport
Chemotaxis
Signaling
Neuron Projection Development
Locomotion
Cell Communication
Anatomical Structure Morphogenesis
Cell Morphogenesis
Axonogenesis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Axon Development
Negative Regulation Of Signaling
Cell Differentiation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Cellular Process
Cell Development
Positive Regulation Of Catalytic Activity
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Neurotrophin Signaling Pathway
System Development
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Cell Morphogenesis Involved In Differentiation
Regulation Of Catalytic Activity
Regulation Of Intracellular Signal Transduction
Movement Of Cell Or Subcellular Component
Cellular Response To Growth Factor Stimulus
Regulation Of Body Fluid Levels
Positive Regulation Of Apoptotic Process
Blood Coagulation
Tagcloud
?
a2m
algorithm
allele
alzheimer
amplicons
apoe
apoj
biochip
clut
combinations
cr1
determina
e3
e4
epsilon2
epsilon4
exoc3l2
gab2
genotyping
immobilized
microchip
oligonucleotides
picalm
predis
rs11136000
sporadic
studying
tion
tomm40
Tagcloud (Difference)
?
a2m
algorithm
allele
alzheimer
amplicons
apoe
apoj
biochip
clut
combinations
cr1
determina
e3
e4
epsilon2
epsilon4
exoc3l2
gab2
genotyping
immobilized
microchip
oligonucleotides
picalm
predis
rs11136000
sporadic
studying
tion
tomm40
Tagcloud (Intersection)
?