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RIN2 and CDKN2A
Number of citations of the paper that reports this interaction (PMID
17955473
)
10
Data Source:
BioGRID
(pull down)
RIN2
CDKN2A
Gene Name
Ras and Rab interactor 2
cyclin-dependent kinase inhibitor 2A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Nuclear Body
Senescence-associated Heterochromatin Focus
Protein Complex
Molecular Function
Small GTPase Regulator Activity
GTPase Activator Activity
Rab Guanyl-nucleotide Exchange Factor Activity
P53 Binding
DNA Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Poly(A) RNA Binding
NF-kappaB Binding
Ubiquitin-protein Transferase Inhibitor Activity
MDM2/MDM4 Family Protein Binding
Biological Process
Endocytosis
Small GTPase Mediated Signal Transduction
Positive Regulation Of Rab GTPase Activity
Regulation Of Catalytic Activity
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Negative Regulation Of Cell-matrix Adhesion
Transcription, DNA-templated
RRNA Processing
Negative Regulation Of Protein Kinase Activity
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Cycle Arrest
Ras Protein Signal Transduction
Negative Regulation Of Cell Proliferation
Apoptotic Mitochondrial Changes
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Growth
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Protein Sumoylation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Senescence-associated Heterochromatin Focus Assembly
Negative Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Export From Nucleus
Somatic Stem Cell Division
Protein Stabilization
Negative Regulation Of Ubiquitin-protein Transferase Activity
Protein K63-linked Ubiquitination
Positive Regulation Of Cell Cycle Arrest
Cellular Senescence
Replicative Senescence
Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Cellular Senescence
Pathways
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
G1 Phase
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Oxidative Stress Induced Senescence
Cellular Senescence
Oncogene Induced Senescence
Drugs
Diseases
GWAS
Bipolar disorder and schizophrenia (
20889312
)
Obesity-related traits (
23251661
)
Abdominal aortic aneurysm (
20622881
)
Breast cancer (
23535729
20453838
)
Coronary artery calcification (
23561647
)
Coronary heart disease (
21626137
21971053
17554300
21378990
)
Endometriosis (
23104006
)
Glioma (
21531791
19578367
)
Intracranial aneurysm (
18997786
20364137
)
Melanoma (
21983787
19578364
)
Myocardial infarction (
17478679
)
Myocardial infarction (early onset) (
19198609
)
Platelet counts (
22139419
)
Type 2 diabetes (
21573907
18372903
20581827
19401414
17463246
17463248
17463249
23209189
)
Protein-Protein Interactions
7 interactors:
BIN1
CDKN2A
EGFR
ERBB2
RAB5A
RAB5B
RAB5C
94 interactors:
ACLY
ACTB
ACTG1
ACTN4
AHNAK
ANKRD12
ARFIP2
BCL2L1
BECN1
CARF
CCDC183
CCND1
CCND2
CCNG1
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2C
CRELD2
CTBP2
DEAF1
E2F1
E4F1
EEF2
EGR1
EPHA3
FN1
GAPDH
GGA1
GGA3
GMNN
GSPT1
HIF1A
HIST3H2BB
HNRNPA2B1
HNRNPC
HNRNPU
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
KAT5
MAPK10
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MMRN1
MTR
MYC
MYL12A
NCL
NMI
ORC4
PCNA
PDCD6
PEX19
PLEKHA8
PPP1R9B
PRKCA
PSMC3
RIN2
RPS7
RUVBL2
SERTAD1
SIVA1
SLC4A1
SMARCA4
SNRPA
SNRPB
TBRG1
TDRD7
TP63
TPI1
TRIP12
TUBA1A
TUBA1C
TUBB
TUBB4B
UBE2A
UBE4B
USP26
WRN
YY1
ZFP91
ZNF227
ZNF410
Entrez ID
54453
1029
HPRD ID
15249
02542
Ensembl ID
ENSG00000132669
ENSG00000147889
Uniprot IDs
A1A4T0
Q8WYP3
G3XAG3
K7PML8
P42771
Q8N726
PDB IDs
1A5E
1BI7
1DC2
2A5E
Enriched GO Terms of Interacting Partners
?
Regulation Of Endocytosis
Ras Protein Signal Transduction
Negative Regulation Of Immature T Cell Proliferation In Thymus
Rab Protein Signal Transduction
Intracellular Signal Transduction
Plasma Membrane To Endosome Transport
Regulation Of Cellular Component Organization
Regulation Of Vesicle-mediated Transport
Negative Regulation Of T Cell Differentiation In Thymus
Small GTPase Mediated Signal Transduction
Endosomal Transport
Regulation Of T Cell Differentiation In Thymus
Negative Regulation Of T Cell Differentiation
Negative Regulation Of Lymphocyte Differentiation
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Alkanesulfonate Metabolic Process
Cellular Protein Localization
Negative Regulation Of T Cell Activation
Negative Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Cell Cycle Arrest
Regulation Of Smooth Muscle Cell Proliferation
Vesicle-mediated Transport
Negative Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Establishment Of Protein Localization
Regulation Of Cell Proliferation
Positive Regulation Of Catalytic Activity
Regulation Of T Cell Differentiation
Lipid Tube Assembly
Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Astrocyte Activation
Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Lymphocyte Activation
Negative Regulation Of Cell-cell Adhesion
Signal Transduction
Phosphatidylinositol-mediated Signaling
Regulation Of T Cell Proliferation
Cytoplasmic Transport
Positive Regulation Of Epithelial Cell Proliferation
Receptor Internalization Involved In Canonical Wnt Signaling Pathway
Regulation Of Endosome Size
Senescence-associated Heterochromatin Focus Assembly
Regulation Of Lymphocyte Differentiation
Negative Regulation Of Leukocyte Activation
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Cycle Process
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Response To Stress
Cellular Response To Stress
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Response To Abiotic Stimulus
Cellular Response To DNA Damage Stimulus
Response To Radiation
Negative Regulation Of Cell Cycle
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle
Cell Division
Cellular Nitrogen Compound Metabolic Process
Response To UV
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Organelle Organization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Replication
DNA Replication Initiation
Nitrogen Compound Metabolic Process
Chromosome Organization
Cellular Metabolic Process
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Cellular Metabolic Process
DNA Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Cellular Response To Radiation
Regulation Of Protein Metabolic Process
DNA-dependent DNA Replication
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle Checkpoint
Regulation Of Cell Proliferation
Cellular Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To Stimulus
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?