PPP1R2 and NEK2

Number of citations of the paper that reports this interaction (PubMedID 12221103)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		PPP1R2	NEK2
Description		protein phosphatase 1 regulatory inhibitor subunit 2	NIMA related kinase 2
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Kinetochore Condensed Chromosome Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Midbody Nuclear Lumen Protein-containing Complex Ciliary Basal Body Intercellular Bridge
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Molecular Function Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Signal Transduction Intracellular Signal Transduction	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion
Pathways			APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs			5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases
GWAS			Red cell distribution width ( 27863252 28957414 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		13 interacting genes: CDK5 CSNK2A1 CSNK2A2 GSK3B LMTK2 NEK2 PIN1 PPP1CA PPP1CC PPP1R9A PPP1R9B TERF2IP TINF2	29 interacting genes: CDC20 CEP250 CHGA CIP2A CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PIN1 PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		5504	4751
HPRD ID		03478	04953
Ensembl ID		ENSG00000184203	ENSG00000117650
Uniprot IDs		P41236	F6U4U2 P51955
PDB IDs			2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Rhythmic Process Protein Phosphatase 1 Binding Protein Kinase CK2 Complex Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Nucleoplasm Tau Protein Binding Negative Regulation Of Proteolysis Kinase Activity Regulation Of Cell Cycle Chromosome Organization Dendritic Spine Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Chromosome, Telomeric Region Shelterin Complex Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Glycogen Metabolic Process PTW/PP1 Phosphatase Complex Hippocampus Development Energy Reserve Metabolic Process Polysaccharide Metabolic Process Positive Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Presynapse Filopodium Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Localization To Chromosome, Telomeric Region Cerebral Cortex Development Telomere Capping Macromolecule Metabolic Process Glutamatergic Synapse Regulation Of Protein Metabolic Process Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Regulation Of Telomere Maintenance Regulation Of Wnt Signaling Pathway Regulation Of Circadian Rhythm Regulation Of Nucleocytoplasmic Transport Protein Autophosphorylation Tau-protein Kinase Activity	Centrosome Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ciliary Basal Body Positive Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Ubiquitin Ligase Activator Activity Positive Regulation Of Organelle Organization Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Checkpoint Regulation Of Microtubule Nucleation Neuron Cellular Homeostasis Regulation Of Centriole-centriole Cohesion Neuronal Cell Body Axon Initial Segment Regulation Of Nuclear Division Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Cell Cycle Phase Transition Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Pole Regulation Of Cell Cycle Acinar Cell Differentiation Synapse Organization Chromosome, Centromeric Region Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Microtubule Polymerization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Hematopoietic Or Lymphoid Organ Development Cell Division Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Trachea Formation PTW/PP1 Phosphatase Complex Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Cytoskeleton Cytosol Regulation Of Circadian Rhythm
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