PPP1R2 and PPP1CC

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, two hybrid, two hybrid)
HPRD (in vitro)

		PPP1R2	PPP1CC
Description		protein phosphatase 1 regulatory inhibitor subunit 2	protein phosphatase 1 catalytic subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Molecular Function Inhibitor Activity	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Signal Transduction Intracellular Signal Transduction	Mitotic Sister Chromatid Segregation MAPK Cascade Blastocyst Development Glycogen Metabolic Process Protein Dephosphorylation Spermatogenesis Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Rhythmic Process Cell Division Positive Regulation Of Glial Cell Proliferation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS			Heart rate ( 23583979)
Interacting Genes		13 interacting genes: CDK5 CSNK2A1 CSNK2A2 GSK3B LMTK2 NEK2 PIN1 PPP1CA PPP1CC PPP1R9A PPP1R9B TERF2IP TINF2	128 interacting genes: ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 IRAK1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R35 PPP1R3A PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SAXO4 SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VCP VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667
Entrez ID		5504	5501
HPRD ID		03478	08911
Ensembl ID		ENSG00000184203	ENSG00000186298
Uniprot IDs		P41236	P36873
PDB IDs			1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28 7SD0 8B5R
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Rhythmic Process Protein Phosphatase 1 Binding Protein Kinase CK2 Complex Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Nucleoplasm Tau Protein Binding Negative Regulation Of Proteolysis Kinase Activity Regulation Of Cell Cycle Chromosome Organization Dendritic Spine Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Chromosome, Telomeric Region Shelterin Complex Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Glycogen Metabolic Process PTW/PP1 Phosphatase Complex Hippocampus Development Energy Reserve Metabolic Process Polysaccharide Metabolic Process Positive Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Presynapse Filopodium Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Localization To Chromosome, Telomeric Region Cerebral Cortex Development Telomere Capping Macromolecule Metabolic Process Glutamatergic Synapse Regulation Of Protein Metabolic Process Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Regulation Of Telomere Maintenance Regulation Of Wnt Signaling Pathway Regulation Of Circadian Rhythm Regulation Of Nucleocytoplasmic Transport Protein Autophosphorylation Tau-protein Kinase Activity	Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Protein Phosphatase Regulator Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine/threonine Phosphatase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphatase Type 1 Complex Phosphorylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Nucleoplasm Protein Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Inclusion Body Assembly Glycogen Binding Disordered Domain Specific Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Generation Of Precursor Metabolites And Energy Microglial Cell Activation Protein Serine Kinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphatase Binding Nucleus Glycogen Metabolic Process Leukocyte Activation Involved In Inflammatory Response Chromatin Remodeling Actin Binding Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process PML Body Type II Interferon-mediated Signaling Pathway Germ Cell Nucleus Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Energy Reserve Metabolic Process Epigenetic Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Astrocyte Activation
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