SPN and CXCL16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPN	CXCL16
Description		sialophorin	C-X-C motif chemokine ligand 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Uropod Basement Membrane Extracellular Space Nucleus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Cell Projection Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Cytokine Activity Chemokine Activity
	Biological Process	Response To Protozoan Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Thymic T Cell Selection Regulation Of Defense Response To Virus Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Leukocyte Tethering Or Rolling Apoptotic Signaling Pathway Regulation Of T Cell Migration Positive Regulation Of T Cell Migration	Receptor-mediated Endocytosis Chemotaxis Signal Transduction T Cell Chemotaxis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Response To Cytokine Response To Type II Interferon Response To Tumor Necrosis Factor Lymphocyte Chemotaxis
Pathways		Cell surface interactions at the vascular wall Basigin interactions	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2	66 interacting genes: ADAMTSL4 APP AQP2 AQP6 AQP9 ARL13B ATP6V0E1 BIK CARD10 CCDC70 CD53 CERS4 CLDN7 CREB3L1 CXCR6 CYSRT1 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GORAB GPR42 GPX8 HHATL HOXA1 KASH5 KIR2DL3 KRT31 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP5-9 LHFPL5 LMNA MDFI MFF MTUS2 MUC1 NBPF19 NEMP1 NOTCH2NLA PEX12 SAR1A SLC10A6 SLC16A2 SLC18A1 SLC39A1 SNCA SPN SSMEM1 STX1A TGM1 TLCD4 TMEM139 TMEM14B TMEM237 TMEM239 TMEM35A TMX2 TSPAN12
Entrez ID		6693	58191
HPRD ID		06770	16103
Ensembl ID		ENSG00000197471	ENSG00000161921
Uniprot IDs		P16150	Q9H2A7
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane To Membrane Docking Disordered Domain Specific Binding Microvillus Membrane Cell Periphery Regulation Of Protein Catabolic Process Cell-cell Adhesion Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Lymphocyte Migration Leukocyte Cell-cell Adhesion Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Lymphocyte Activation Leukocyte Migration Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Protein Catabolic Process Uropod Apical Part Of Cell Membrane Docking Layer Formation In Cerebral Cortex Postsynaptic Density, Intracellular Component Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of ERAD Pathway Cell Adhesion Mononuclear Cell Migration Membrane Cell Migration Regulation Of Protein Localization T Cell Activation Leukocyte Activation Establishment Of Apical/basal Cell Polarity Negative Regulation Of Protein Catabolic Process Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of ERAD Pathway Epithelial Cell Development Plasma Membrane Regulation Of Cell Shape Positive Regulation Of Intracellular Transport Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell Activation Cell Motility Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Intermediate Filament Keratin Filament Membrane Water Channel Activity Identical Protein Binding Cellular Response To Copper Ion Water Transport
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