SPN and ICAM1

Number of citations of the paper that reports this interaction (PMID 1683685)
36

Data Source:
HPRD (in vitro)

		SPN	ICAM1
Gene Name		sialophorin	intercellular adhesion molecule 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Uropod Basement Membrane Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding	Virus Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding
	Biological Process	Response To Protozoan Negative Regulation Of Type IV Hypersensitivity Positive Regulation Of Protein Phosphorylation Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway Blood Coagulation T Cell Costimulation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Negative Thymic T Cell Selection Regulation Of Defense Response To Virus Leukocyte Migration Apoptotic Signaling Pathway	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Virus Response To Ionizing Radiation Response To Sulfur Dioxide Response To Organic Cyclic Compound Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Positive Regulation Of Rho GTPase Activity Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Basigin interactions Cell surface interactions at the vascular wall	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs			Natalizumab Hyaluronan
Diseases
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Soluble ICAM-1 ( 21533024 18604267)
Protein-Protein Interactions		8 interactors: CTNNB1 DAXX EZR FYN ICAM1 LGALS1 MSN SIGLEC1	12 interactors: EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 MSN SLC3A2 SPN
Entrez ID		6693	3383
HPRD ID		06770	00996
Ensembl ID		ENSG00000197471	ENSG00000090339
Uniprot IDs		A8K9B1 P16150	B4DQW5 E7ESS4 P05362
PDB IDs			1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX
Enriched GO Terms of Interacting Partners?		Establishment Of Endothelial Barrier Membrane To Membrane Docking Endothelial Cell Development Single Organismal Cell-cell Adhesion Endothelial Cell Differentiation Endothelium Development Leukocyte Cell-cell Adhesion Epithelial Cell Development Cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Membrane Docking Lymphocyte Activation Regulation Of Cell Morphogenesis Leukocyte Activation Response To Drug Regulation Of Cell Shape Epithelial Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Locomotion Regulation Of Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Cell Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Movement Of Cell Or Subcellular Component Leukocyte Migration Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Androgen Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Myoblast Differentiation Regulation Of Neuron Death Cell Migration Regulation Of T Cell Activation Regulation Of Intracellular Signal Transduction Regulation Of Signaling Cell Development Cell Motility Homotypic Cell-cell Adhesion Regulation Of Cellular Component Organization Cellular Response To Glucose Stimulus Cell Differentiation Regulation Of Cell-cell Adhesion Response To Stress	Single Organismal Cell-cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Cell Adhesion Locomotion Blood Coagulation Hemostasis Cell Migration Cell Motility Immune System Process Movement Of Cell Or Subcellular Component Activated T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Homotypic Cell-cell Adhesion Cell Activation Response To Wounding Immune Response Regulation Of Immune System Process Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response Membrane To Membrane Docking T Cell Proliferation Positive Regulation Of Cell-cell Adhesion Chemotaxis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Positive Regulation Of T Cell Proliferation Leukocyte Aggregation Response To Interleukin-2 Leukocyte Migration Involved In Inflammatory Response Cell Proliferation Lymphocyte Proliferation Defense Response Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Leukocyte Proliferation Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Lymphocyte Activation Inflammatory Response Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Response To Stress Cellular Extravasation
Tagcloud ?			baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Difference) ?			baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Intersection) ?