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SPN and DAXX
Number of citations of the paper that reports this interaction (PubMedID
11773067
)
0
Data Source:
HPRD
(two hybrid)
SPN
DAXX
Description
sialophorin
death domain associated protein
Image
No pdb structure
GO Annotations
Cellular Component
Uropod
Basement Membrane
Extracellular Space
Nucleus
Plasma Membrane
Microvillus
External Side Of Plasma Membrane
Cell Surface
Membrane
PML Body
Cell Projection
Extracellular Exosome
Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
PML Body
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Protein Homodimerization Activity
Nuclear Androgen Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Molecular Condensate Scaffold Activity
Biological Process
Response To Protozoan
Negative Regulation Of Type IV Hypersensitivity
T-helper 1 Cell Lineage Commitment
Chemotaxis
Immune Response
Cellular Defense Response
Negative Regulation Of Cell Adhesion
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
Cell Surface Receptor Signaling Pathway
T Cell Costimulation
Positive Regulation Of Tumor Necrosis Factor Production
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Negative Regulation Of T Cell Proliferation
Defense Response To Bacterium
Negative Thymic T Cell Selection
Regulation Of Defense Response To Virus
Regulation Of Immune Response
Regulation Of T Cell Activation
Negative Regulation Of T Cell Activation
Leukocyte Tethering Or Rolling
Apoptotic Signaling Pathway
Regulation Of T Cell Migration
Positive Regulation Of T Cell Migration
Chromatin Organization
Nucleosome Assembly
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Apoptotic Process
JNK Cascade
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Androgen Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Cellular Response To Heat
Cellular Response To Unfolded Protein
Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Diamide
Cellular Response To Sodium Arsenite
Pathways
Cell surface interactions at the vascular wall
Basigin interactions
SUMOylation of transcription cofactors
Regulation of TP53 Degradation
HCMV Early Events
Inhibition of DNA recombination at telomere
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Autism spectrum disorder or schizophrenia (
28540026
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Interacting Genes
18 interacting genes:
ARL13B
CLCA4
CTNNB1
CTSA
CXCL16
CYBC1
DAXX
ERGIC3
EZR
FYN
ICAM1
LGALS1
LMNA
MSN
PLP2
SGTA
SIGLEC1
UBQLN2
114 interacting genes:
ACVR2A
AIRE
AMOTL2
AR
ATM
ATRX
BTBD6
CA12
CALCOCO2
CARD9
CARM1
CBS
CDCA7L
CENPC
CEP63
CEP70
CFLAR
CREBBP
CSNK2A1
CSNK2B
DAPK3
DKC1
DMAP1
DNMT1
DRC4
ESRRG
ETS1
FAM9B
FANCA
FAS
FASLG
FTH1
GOLGA2
GOLGA6L9
GRIPAP1
H3-3B
H3-5
H3C3
H4C16
HABP4
HBA1
HDAC1
HDAC2
HDAC3
HIPK1
HIPK2
HIPK3
HSF1
HSF4
HSPB1
KCTD4
MAP3K5
MCRS1
MDM2
MEN1
MIPOL1
MKRN1
MSANTD4
MX1
MYH11
NECAB2
NSD3
PARK7
PAX3
PAX5
PBXIP1
PIBF1
PLAGL1
PML
PNMA1
PRMT1
PTEN
RASSF1
RASSF3
RIPK3
RNF4
RPL13
SENP2
SERBP1
SLC2A4
SLC9A1
SNW1
SPN
SPOP
SQSTM1
SSX2IP
STAT3
STK4
STUB1
SUMO1
SUMO2
SUMO3
TAX1BP1
TCF3
TCF4
TCF7L2
TFIP11
TGFB1
TGFBR2
TNFRSF1A
TP53
TP63
TP73
TRAF3
TRIM21
TRIM54
TSG101
UBC
UBE2I
USH1G
USP7
WEE2-AS1
ZBTB2
ZBTB26
Entrez ID
6693
1616
HPRD ID
06770
04424
Ensembl ID
ENSG00000197471
ENSG00000204209
Uniprot IDs
P16150
A0A024RCS3
B4E1C1
Q53F85
Q9UER7
PDB IDs
2KQS
2KZS
2KZU
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
5GRQ
5KDM
5Y18
5Y6O
Enriched GO Terms of Interacting Partners
?
Membrane To Membrane Docking
Disordered Domain Specific Binding
Microvillus Membrane
Cell Periphery
Regulation Of Protein Catabolic Process
Cell-cell Adhesion
Establishment Of Endothelial Barrier
T Cell Migration
Endothelial Cell Development
Lymphocyte Migration
Leukocyte Cell-cell Adhesion
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Localization To Early Endosome
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Lymphocyte Activation
Leukocyte Migration
Positive Regulation Of Protein Localization To Endosome
Positive Regulation Of Protein Catabolic Process
Uropod
Apical Part Of Cell
Membrane Docking
Layer Formation In Cerebral Cortex
Postsynaptic Density, Intracellular Component
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Early Endosome To Late Endosome Transport
Establishment Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of ERAD Pathway
Cell Adhesion
Mononuclear Cell Migration
Membrane
Cell Migration
Regulation Of Protein Localization
T Cell Activation
Leukocyte Activation
Establishment Of Apical/basal Cell Polarity
Negative Regulation Of Protein Catabolic Process
Polarized Epithelial Cell Differentiation
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Regulation Of ERAD Pathway
Epithelial Cell Development
Plasma Membrane
Regulation Of Cell Shape
Positive Regulation Of Intracellular Transport
Gland Morphogenesis
Establishment Of Epithelial Cell Polarity
Cell Activation
Cell Motility
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
PML Body
Identical Protein Binding
Nucleus
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
PML Body Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear Body
Regulation Of Gene Expression
Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Programmed Cell Death
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