SPN and LGALS1

Number of citations of the paper that reports this interaction (PubMedID 10490978)
0

Data Source:
HPRD (in vitro, in vivo)

		SPN	LGALS1
Description		sialophorin	galectin 1
Image		No pdb structure
GO Annotations	Cellular Component	Uropod Basement Membrane Extracellular Space Nucleus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Cell Projection Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Extracellular Matrix Extracellular Exosome Galectin Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding	RNA Binding Protein Binding Carbohydrate Binding Lactose Binding Laminin Binding Receptor Ligand Activity
	Biological Process	Response To Protozoan Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Thymic T Cell Selection Regulation Of Defense Response To Virus Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Leukocyte Tethering Or Rolling Apoptotic Signaling Pathway Regulation Of T Cell Migration Positive Regulation Of T Cell Migration	Plasma Cell Differentiation Apoptotic Process Signal Transduction T Cell Costimulation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Myoblast Differentiation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Inflammatory Response Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Dendritic Cell Differentiation
Pathways		Cell surface interactions at the vascular wall Basigin interactions	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Mercaptoethanol Thiodigalactoside 1,4-Dithiothreitol Artenimol OTX-008
Diseases
GWAS			Fat distribution (HIV) ( 21897333)
Interacting Genes		18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2	17 interacting genes: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS HSPB2 ITGB1 LGALS3BP MUC16 NLGN3 PTEN PTPRC SPN USP4 VPREB1
Entrez ID		6693	3956
HPRD ID		06770	01040
Ensembl ID		ENSG00000197471	ENSG00000100097
Uniprot IDs		P16150	A0A384MR27 P09382
PDB IDs			1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z 8OJP 8R74 8RDC
Enriched GO Terms of Interacting Partners?		Membrane To Membrane Docking Disordered Domain Specific Binding Microvillus Membrane Cell Periphery Regulation Of Protein Catabolic Process Cell-cell Adhesion Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Lymphocyte Migration Leukocyte Cell-cell Adhesion Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Lymphocyte Activation Leukocyte Migration Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Protein Catabolic Process Uropod Apical Part Of Cell Membrane Docking Layer Formation In Cerebral Cortex Postsynaptic Density, Intracellular Component Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of ERAD Pathway Cell Adhesion Mononuclear Cell Migration Membrane Cell Migration Regulation Of Protein Localization T Cell Activation Leukocyte Activation Establishment Of Apical/basal Cell Polarity Negative Regulation Of Protein Catabolic Process Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of ERAD Pathway Epithelial Cell Development Plasma Membrane Regulation Of Cell Shape Positive Regulation Of Intracellular Transport Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell Activation Cell Motility Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	External Side Of Plasma Membrane Lymphocyte Activation T Cell Activation Leukocyte Activation Cell Adhesion Cell Activation Immune System Process T Cell Selection Rhythmic Synaptic Transmission Signaling Receptor Activity Heterotypic Cell-cell Adhesion Positive Regulation Of Cytokine Production Mononuclear Cell Differentiation Positive Regulation Of Cell Population Proliferation Cellular Defense Response Membrane Raft Distribution Cell Surface Membrane Raft Localization Leukocyte Differentiation Coreceptor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Presynaptic Membrane Assembly Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Presynaptic Membrane Organization Regulation Of Adaptive Immune Response Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Negative Thymic T Cell Selection Positive Regulation Of Signal Transduction Negative T Cell Selection Regulation Of Cytokine Production Cell-cell Adhesion Immune Response Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Lymphocyte Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Mediated Immunity Dendritic Spine Morphogenesis Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of T Cell Proliferation T Cell Receptor Complex T Cell Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
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