SPN and SIGLEC1

Number of citations of the paper that reports this interaction (PMID 11238599)
26

Data Source:
HPRD (in vivo)

		SPN	SIGLEC1
Gene Name		sialophorin	sialic acid binding Ig-like lectin 1, sialoadhesin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Uropod Basement Membrane Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding	Carbohydrate Binding
	Biological Process	Response To Protozoan Negative Regulation Of Type IV Hypersensitivity Positive Regulation Of Protein Phosphorylation Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway Blood Coagulation T Cell Costimulation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Negative Thymic T Cell Selection Regulation Of Defense Response To Virus Leukocyte Migration Apoptotic Signaling Pathway	Endocytosis Inflammatory Response Cell-matrix Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CTNNB1 DAXX EZR FYN ICAM1 LGALS1 MSN SIGLEC1	3 interactors: MUC1 SPN TNR
Entrez ID		6693	6614
HPRD ID		06770	02854
Ensembl ID		ENSG00000197471	ENSG00000088827
Uniprot IDs		A8K9B1 P16150	Q9BZZ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Endothelial Barrier Membrane To Membrane Docking Endothelial Cell Development Single Organismal Cell-cell Adhesion Endothelial Cell Differentiation Endothelium Development Leukocyte Cell-cell Adhesion Epithelial Cell Development Cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Membrane Docking Lymphocyte Activation Regulation Of Cell Morphogenesis Leukocyte Activation Response To Drug Regulation Of Cell Shape Epithelial Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Locomotion Regulation Of Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Cell Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Movement Of Cell Or Subcellular Component Leukocyte Migration Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Androgen Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Myoblast Differentiation Regulation Of Neuron Death Cell Migration Regulation Of T Cell Activation Regulation Of Intracellular Signal Transduction Regulation Of Signaling Cell Development Cell Motility Homotypic Cell-cell Adhesion Regulation Of Cellular Component Organization Cellular Response To Glucose Stimulus Cell Differentiation Regulation Of Cell-cell Adhesion Response To Stress	Associative Learning Negative Regulation Of Cell-cell Adhesion Learning Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Cell Adhesion Negative Regulation Of Type IV Hypersensitivity Learning Or Memory Cognition Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Cell-cell Adhesion Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Axon Regeneration Positive Regulation Of Transmission Of Nerve Impulse Single-organism Behavior Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Single Organismal Cell-cell Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Thymic T Cell Selection Negative Regulation Of Acute Inflammatory Response Negative Regulation Of T Cell Mediated Immunity Negative T Cell Selection Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Behavior Chemotaxis Neuron Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Histone H4 Acetylation Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Axon Regeneration Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Histone Acetylation Thymic T Cell Selection Positive Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Axon Extension Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Acetylation Response To Protozoan Exploration Behavior Cell Migration Cell Motility
Tagcloud ?			alternative biomarker ccr1 cd14 cluster clustering clusters complication cutaneous diffuse distinguished exclusively greatly hierarchical idiopathic ifn il13ra1 immunoassay lcssc messenger monocyte mononuclear mrc1 mx1 pah pbmc pbmcs ssc supervised
Tagcloud (Difference) ?			alternative biomarker ccr1 cd14 cluster clustering clusters complication cutaneous diffuse distinguished exclusively greatly hierarchical idiopathic ifn il13ra1 immunoassay lcssc messenger monocyte mononuclear mrc1 mx1 pah pbmc pbmcs ssc supervised
Tagcloud (Intersection) ?