UBASH3A and SPRY2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		UBASH3A	SPRY2
Gene Name		ubiquitin associated and SH3 domain containing A	sprouty homolog 2 (Drosophila)
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome	Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Ruffle Membrane
	Molecular Function		Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway	Establishment Of Mitotic Spindle Orientation Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways			Signaling by EGFR EGFR downregulation Signaling by FGFR in disease Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 18840781) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)	Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) Orofacial clefts ( 20023658 22863734) Type 2 diabetes ( 20862305)
Protein-Protein Interactions		14 interactors: CBL CBS DAZAP2 KCNE1 KRT40 PARK2 REL SF3B4 SPRY2 TP53BP2 TRIM37 UBB UBC UBE2L3	90 interactors: ADAMTSL4 AQP1 ATRIP C19orf66 CATSPER1 CBL CBLB CBLC CHRD CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 HEXIM2 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PTGER3 PTPN11 RAF1 RTFDC1 RUNX1T1 SDHB SEMA5B SH3KBP1 SIAH2 SPRY1 STK16 TCAF1 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587
Entrez ID		53347	10253
HPRD ID		06904	03916
Ensembl ID		ENSG00000160185	ENSG00000136158
Uniprot IDs		P57075	O43597
PDB IDs		2CRN	3BUM 3OB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Ubiquitination I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Transferase Activity Viral Protein Processing Positive Regulation Of Protein Metabolic Process Aggresome Assembly Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Glycogen Biosynthetic Process Intracellular Transport Of Virus	Negative Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Keratinization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process Keratinocyte Differentiation Regulation Of Cell Activation Negative Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Cell Death System Development Death Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Developmental Process Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of T Cell Activation Cellular Response To Organic Substance Cell Differentiation Anatomical Structure Development Organ Development Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Epidermal Cell Differentiation Response To Growth Factor Protein Modification By Small Protein Conjugation Epithelium Development Regulation Of Apoptotic Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Kinase Activity Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?			beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Difference) ?			beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Intersection) ?