UBASH3A

Gene Name		ubiquitin associated and SH3 domain containing A
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 18840781) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)
Protein-protein Interactions		14 interactors: CBL CBS DAZAP2 KCNE1 KRT40 PARK2 REL SF3B4 SPRY2 TP53BP2 TRIM37 UBB UBC UBE2L3
Entrez ID		53347
HPRD ID		06904
Ensembl ID		ENSG00000160185
Uniprot IDs		P57075
PDB IDs		2CRN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Ubiquitination I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Transferase Activity Viral Protein Processing Positive Regulation Of Protein Metabolic Process Aggresome Assembly Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Glycogen Biosynthetic Process Intracellular Transport Of Virus
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