UBASH3A and WBP11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBASH3A	WBP11
Description		ubiquitin associated and SH3 domain containing A	WW domain binding protein 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway	RRNA Processing RNA Processing MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		105 interacting genes: ARRDC1 ARRDC3 ATF6 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1	37 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CEBPA CTNNBL1 DDX17 DDX5 FOXP1 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PCBP4 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRMT2 PRPF40A RBM5 RSPH1 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4
Entrez ID		53347	51729
HPRD ID		06904	18293
Ensembl ID		ENSG00000160185	ENSG00000084463
Uniprot IDs		P57075	Q9Y2W2
PDB IDs		2CRN 5WDI	7ABF 7ABG
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity	Nuclear Speck Proline-rich Region Binding Cytosol RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome PTW/PP1 Phosphatase Complex Nucleus RNA Splicing Ribonucleoprotein Complex Binding Cytoplasm Regulation Of RNA Splicing Nucleoplasm MRNA Processing Protein Domain Specific Binding Regulation Of Defense Response Protein-containing Complex Binding Regulation Of Gene Expression Scaffold Protein Binding Entrainment Of Circadian Clock By Photoperiod Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Nuclear Androgen Receptor Binding Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ephrin Receptor Binding Photoperiodism Entrainment Of Circadian Clock Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process MRNA Metabolic Process Regulation Of Innate Immune Response Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Neurotrophin TRKA Receptor Binding Regulation Of MRNA Metabolic Process Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Developmental Process Regulation Of Immune System Process Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Signal Complex Assembly T Cell Costimulation
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