C1S and REEP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C1S	REEP4
Description		complement C1s	receptor accessory protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Blood Microparticle Symbiont Cell Surface	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Cytoplasmic Microtubule Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Microtubule Binding
	Biological Process	Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation	Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form Sutimlimab
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Activated partial thromboplastin time ( 29403010) Alzheimer's disease ( 33654092) Coronary artery disease ( 29212778 33020668) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lung cancer in never smokers ( 28604730) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278)	Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)
Interacting Genes		6 interacting genes: C1QA C1R PKNOX1 REEP4 SERPING1 VKORC1	101 interacting genes: AGPAT4 ARLN BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 NINJ2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM14B TMEM167B TMEM18 TMEM19 TMEM208 TMEM229B TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VMA12 VTI1B YIF1A YIPF4 YIPF6
Entrez ID		716	80346
HPRD ID		00397	09864
Ensembl ID		ENSG00000182326	ENSG00000168476
Uniprot IDs		F8WCZ6 P09871	E5RGS2 Q9H6H4
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H 8GMN 8TYP
Enriched GO Terms of Interacting Partners?		Complement Component C1 Complex Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Coagulation Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis IMP Dehydrogenase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Microparticle Leukocyte Activation Complement Component C1q Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Activation IgM Binding Extrinsic Component Of Postsynaptic Membrane 'de Novo' XMP Biosynthetic Process Immune System Process Synapse Pruning GTP Biosynthetic Process Quinone Binding Mitotic Nuclear Membrane Reassembly Extracellular Region Regulation Of Immune Response Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Negative Regulation Of Complement Activation Neuron Remodeling Humoral Immune Response IgG Binding Activation Of Membrane Attack Complex GMP Biosynthetic Process Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Molecular Sequestering Activity Opsonization Astrocyte Activation Fibrinolysis Purine Ribonucleoside Monophosphate Biosynthetic Process GTP Metabolic Process Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Regulation Of Complement Activation Nuclear Envelope Organization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endomembrane System SNAP Receptor Activity SNARE Complex Protein Binding Establishment Of Protein Localization Organelle Fusion Vesicle Fusion Organelle Membrane Fusion Mitochondrial Outer Membrane Membrane Fusion Membrane Organization Vesicle Fusion With Golgi Apparatus Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Docking Protein Transport Presynaptic Endosome Membrane Golgi Vesicle Transport Monoatomic Ion Transmembrane Transporter Activity Intracellular Transport Cellular Localization Mitochondrial Membrane Nitric-oxide Synthase Complex Vesicle Organization Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Serine Import Into Mitochondrion Olfactory Receptor Binding Establishment Of Localization In Cell Myelination Axon Ensheathment Nitrite Reductase (NO-forming) Activity Transport Vesicle Golgi Membrane Vesicle Docking Menaquinone Metabolic Process SNARE Binding Golgi Organization Import Into The Mitochondrion Bcl-2 Family Protein Complex Mitochondrial Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?