C1S

Name	complement C1s
Structure
Novel Interactors	1 novel interactors: IMPDH2
Interactors	6 interactors: C1QA C1R PKNOX1 REEP4 SERPING1 VKORC1
GO Annotations	Cellular Component	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Blood Microparticle Symbiont Cell Surface
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs	Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form Sutimlimab
Diseases	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS	Activated partial thromboplastin time ( 29403010 ) Alzheimer's disease ( 33654092 ) Coronary artery disease ( 29212778 33020668 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Lung cancer in never smokers ( 28604730 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell fatty acid levels ( 25500335 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 )
Entrez ID	716
HPRD ID	00397
Ensembl ID	ENSG00000182326
Uniprot IDs	F8WCZ6 P09871
PDB IDs	1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H 8GMN 8TYP
GO Terms Enriched among Interactors ?	Complement Component C1 Complex Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Coagulation Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis IMP Dehydrogenase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Microparticle Leukocyte Activation Complement Component C1q Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Activation IgM Binding Extrinsic Component Of Postsynaptic Membrane 'de Novo' XMP Biosynthetic Process Immune System Process Synapse Pruning GTP Biosynthetic Process Quinone Binding Mitotic Nuclear Membrane Reassembly Extracellular Region Regulation Of Immune Response Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Negative Regulation Of Complement Activation Neuron Remodeling Humoral Immune Response IgG Binding Activation Of Membrane Attack Complex GMP Biosynthetic Process Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Molecular Sequestering Activity Opsonization Astrocyte Activation Fibrinolysis Purine Ribonucleoside Monophosphate Biosynthetic Process GTP Metabolic Process Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Regulation Of Complement Activation Nuclear Envelope Organization