C1S

Gene Name		complement component 1, s subcomponent
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid
Diseases
GWAS
Protein-protein Interactions		4 interactors: C1QA C1R SERPING1 VKORC1
Entrez ID		716
HPRD ID		00397
Ensembl ID		ENSG00000182326
Uniprot IDs		F8WCZ6 P09871
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Immune Response Regulation Of Immune System Process Defense Response Vitamin K Metabolic Process Blood Coagulation Hemostasis Negative Regulation Of Complement Activation Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Immune System Process Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Fibrinolysis Response To Wounding Regulation Of Complement Activation Negative Regulation Of Innate Immune Response Quinone Metabolic Process Drug Metabolic Process Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Platelet Degranulation Cellular Ketone Metabolic Process Response To Stimulus Regulation Of Blood Coagulation Vitamin Metabolic Process Negative Regulation Of Immune Response Regulation Of Wound Healing
Tagcloud ?		c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields