C1S and C1R

Number of citations of the paper that reports this interaction (PMID 10092586)
12

Data Source:
HPRD (in vivo, in vitro)

		C1S	C1R
Gene Name		complement component 1, s subcomponent	complement component 1, r subcomponent
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response	Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid
Diseases
GWAS
Protein-Protein Interactions		4 interactors: C1QA C1R SERPING1 VKORC1	7 interactors: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		716	715
HPRD ID		00397	01954
Ensembl ID		ENSG00000182326
Uniprot IDs		F8WCZ6 P09871	P00736
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS	1APQ 1GPZ 1MD7 1MD8 2QY0
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Immune Response Regulation Of Immune System Process Defense Response Vitamin K Metabolic Process Blood Coagulation Hemostasis Negative Regulation Of Complement Activation Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Immune System Process Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Fibrinolysis Response To Wounding Regulation Of Complement Activation Negative Regulation Of Innate Immune Response Quinone Metabolic Process Drug Metabolic Process Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Platelet Degranulation Cellular Ketone Metabolic Process Response To Stimulus Regulation Of Blood Coagulation Vitamin Metabolic Process Negative Regulation Of Immune Response Regulation Of Wound Healing	Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Innate Immune Response Immune Response Defense Response Positive Regulation Of Immune Response Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune System Process Regulation Of Immune System Process Histone H2B Acetylation Glycerol Biosynthetic Process From Pyruvate Internal Protein Amino Acid Acetylation Negative Regulation Of Complement Activation, Lectin Pathway Response To Stimulus Protein Acetylation N-terminal Peptidyl-lysine Acetylation Glycerol Biosynthetic Process Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Positive Regulation By Host Of Viral Transcription Rhythmic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of Complement Activation Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Oxaloacetate Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification
Tagcloud ?		c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields	a2 allogeneic autologous candidates cold ctl ctls demonstrating encoded epitopes gastric her2 hla ic50 immunodominance immunotherapy implicate lymphocyte lysed naturally neu processed recognized repetitive restricted sensitize sw626 tal transfected
Tagcloud (Difference) ?		c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields	a2 allogeneic autologous candidates cold ctl ctls demonstrating encoded epitopes gastric her2 hla ic50 immunodominance immunotherapy implicate lymphocyte lysed naturally neu processed recognized repetitive restricted sensitize sw626 tal transfected
Tagcloud (Intersection) ?