C1S and C1R

Number of citations: 0 (PubMedID 9477945)
Data Source: HPRD (in vitro, in vivo)

		C1S	C1R
Name		complement C1s	complement C1r
Structure
GO Annotations	Cellular Component	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Blood Microparticle Symbiont Cell Surface	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Molecular Sequestering Activity
	Biological Process	Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation	Activation Of Membrane Attack Complex Immune System Process Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form Sutimlimab	Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Activated partial thromboplastin time ( 29403010 ) Alzheimer's disease ( 33654092 ) Coronary artery disease ( 29212778 33020668 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Lung cancer in never smokers ( 28604730 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell fatty acid levels ( 25500335 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: IMPDH2	1 novel interactors: TUBGCP2
Interacting Genes		6 interacting genes: C1QA C1R PKNOX1 REEP4 SERPING1 VKORC1	7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		716	715
HPRD ID		00397	01954
Ensembl ID		ENSG00000182326	ENSG00000159403
Uniprot IDs		F8WCZ6 P09871	A0A3B3ISR2 B4DPQ0 P00736
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H 8GMN 8TYP	1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39 9EKD 9EKE
GO Terms Enriched among Interactors		Complement Component C1 Complex Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Coagulation Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis IMP Dehydrogenase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Microparticle Leukocyte Activation Complement Component C1q Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Activation IgM Binding Extrinsic Component Of Postsynaptic Membrane 'de Novo' XMP Biosynthetic Process Immune System Process Synapse Pruning GTP Biosynthetic Process Quinone Binding Mitotic Nuclear Membrane Reassembly Extracellular Region Regulation Of Immune Response Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Negative Regulation Of Complement Activation Neuron Remodeling Humoral Immune Response IgG Binding Activation Of Membrane Attack Complex GMP Biosynthetic Process Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Molecular Sequestering Activity Opsonization Astrocyte Activation Fibrinolysis Purine Ribonucleoside Monophosphate Biosynthetic Process GTP Metabolic Process Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Regulation Of Complement Activation Nuclear Envelope Organization	Complement Component C1 Complex Symbiont Cell Surface Complement Component C1q Complex Complement Activation, Classical Pathway Regulation Of Immune Response IgM Binding Complement Activation Positive Regulation Of Immune Response Synapse Pruning Regulation Of Immune System Process IgG Binding Blood Microparticle Activation Of Immune Response Tricarboxylic Acid Metabolic Process Positive Regulation Of Immune System Process Humoral Immune Response Gluconeogenesis Phosphatidylserine Binding Protein Maturation Hexose Biosynthetic Process Pyruvate Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Protein Serine Kinase Activity (using GTP As Donor) Collagen Trimer Immune Effector Process Negative Regulation Of Complement Activation, Lectin Pathway Extracellular Matrix Response To Stress Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process Response To Other Organism Protein Localization To Chromosome Carbohydrate Biosynthetic Process Vertebrate Eye-specific Patterning