C1S and SERPING1

Number of citations of the paper that reports this interaction (PMID 3756141)
46

Data Source:
HPRD (in vitro, in vivo)

		C1S	SERPING1
Gene Name		complement component 1, s subcomponent	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Platelet Activation Fibrinolysis Innate Immune Response
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: C1QA C1R SERPING1 VKORC1	13 interactors: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP
Entrez ID		716	710
HPRD ID		00397	06033
Ensembl ID		ENSG00000182326	ENSG00000149131
Uniprot IDs		F8WCZ6 P09871	B4E1F0 E9KL26 P05155
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS	1M6Q 2OAY
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Immune Response Regulation Of Immune System Process Defense Response Vitamin K Metabolic Process Blood Coagulation Hemostasis Negative Regulation Of Complement Activation Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Immune System Process Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Fibrinolysis Response To Wounding Regulation Of Complement Activation Negative Regulation Of Innate Immune Response Quinone Metabolic Process Drug Metabolic Process Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Platelet Degranulation Cellular Ketone Metabolic Process Response To Stimulus Regulation Of Blood Coagulation Vitamin Metabolic Process Negative Regulation Of Immune Response Regulation Of Wound Healing	Immune System Process Response To Stress Defense Response Proteolysis Protein Activation Cascade Regulation Of Immune System Process Leukocyte Migration Cell Migration Positive Regulation Of Immune System Process Cell Motility Regulation Of Blood Coagulation Fibrinolysis Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Complement Activation Negative Regulation Of Protein Processing Response To Stimulus Positive Regulation Of Coagulation Locomotion Regulation Of Protein Processing Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Movement Of Cell Or Subcellular Component Complement Activation, Lectin Pathway Humoral Immune Response Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels Leukocyte Mediated Immunity Wound Healing Negative Regulation Of Fibrinolysis Positive Regulation Of Immune Response Response To Wounding Leukocyte Tethering Or Rolling Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Immune Response Complement Activation, Classical Pathway Innate Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Lipid Inflammatory Response Cellular Extravasation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Platelet Activation
Tagcloud ?		c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields	2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg
Tagcloud (Difference) ?		c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields	2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg
Tagcloud (Intersection) ?