C1S and C1QA

Number of citations of the paper that reports this interaction (PMID 10878362)
11

Data Source:
HPRD (in vitro)

		C1S	C1QA
Gene Name		complement component 1, s subcomponent	complement component 1, q subcomponent, A chain
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response	Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Innate Immune Response
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid
Diseases
GWAS
Protein-Protein Interactions		4 interactors: C1QA C1R SERPING1 VKORC1	25 interactors: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG PIAS2 PPP1CA PPP1CC PTX3 SGTA SLC25A47 UBQLN1 UBQLN2
Entrez ID		716	712
HPRD ID		00397	00393
Ensembl ID		ENSG00000182326	ENSG00000173372
Uniprot IDs		F8WCZ6 P09871	P02745
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS	1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Immune Response Regulation Of Immune System Process Defense Response Vitamin K Metabolic Process Blood Coagulation Hemostasis Negative Regulation Of Complement Activation Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Immune System Process Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Fibrinolysis Response To Wounding Regulation Of Complement Activation Negative Regulation Of Innate Immune Response Quinone Metabolic Process Drug Metabolic Process Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Platelet Degranulation Cellular Ketone Metabolic Process Response To Stimulus Regulation Of Blood Coagulation Vitamin Metabolic Process Negative Regulation Of Immune Response Regulation Of Wound Healing	Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Defense Response Protein Metabolic Process Positive Regulation Of Immune Response Immune System Process Innate Immune Response Response To Stress Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Acute-phase Response Response To Stimulus Regulation Of Protein Metabolic Process Dermatan Sulfate Biosynthetic Process Opsonization Regulation Of Acute Inflammatory Response Acute Inflammatory Response Negative Regulation Of Signal Transduction Negative Regulation Of Glycoprotein Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Signaling Extracellular Matrix Disassembly Negative Regulation Of Viral Entry Into Host Cell Proteoglycan Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Triglyceride Catabolic Process Chondroitin Sulfate Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Wound Healing Chondroitin Sulfate Proteoglycan Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process
Tagcloud ?		c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields	abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant
Tagcloud (Difference) ?		c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields	abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant
Tagcloud (Intersection) ?