PIN4 and EZH2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PIN4	EZH2
Gene Name		protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)	enhancer of zeste 2 polycomb repressive complex 2 subunit
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrial Matrix Spindle Preribosome Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function	DNA Binding Bent DNA Binding Double-stranded DNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Poly(A) RNA Binding	Core Promoter Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Protein Peptidyl-prolyl Isomerization RRNA Processing	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Cortex Development Positive Regulation Of Ras GTPase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ASCC2 CEP72 CSNK2A1 CSNK2A2 DNM1 EGFR EZH2 FAM9B FATE1 FBL MAGEA11 PNMA1 SPTAN1 ZBTB9	64 interactors: AKT1 ATP1A1 ATP1B1 ATRX BRCA1 C7orf25 CCDC85B CDK1 CDK2 CDK6 CDKN2B-AS1 CEP63 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 GADD45G GTF3C1 HDAC1 HIST1H1A HIST1H3A HIST3H3 HOTAIR JAK2 KDM1A KLHDC2 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRMT5 PSMB6 RASA1 RBBP4 RBL2 RELA RELB RPN2 RPS6KA5 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 USP7 VAV1 WDR61 WSB2 ZAK ZMYND11
Entrez ID		5303	2146
HPRD ID		02219	03342
Ensembl ID		ENSG00000102309	ENSG00000106462
Uniprot IDs		Q9Y237	Q15910 S4S3R8
PDB IDs		1EQ3 1FJD 3UI4 3UI5 3UI6	2C6V 4MI0
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Negative Regulation Of Mitotic Cell Cycle Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Negative Regulation Of Protein Catabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Mitotic Cell Cycle Generation Of Neurons Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Neurogenesis Neuron Development Cell Cycle Process Cell Morphogenesis Neuron Differentiation Cell Projection Organization Regulation Of Mitotic Cell Cycle Phase Transition Locomotion Regulation Of Cell Cycle Phase Transition Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Mitotic Cell Cycle Process Cell Cycle Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Cell Differentiation Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Rhythmic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Alkanesulfonate Metabolic Process Histone Glutamine Methylation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Cell Division Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Cell Development Response To External Stimulus	Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Methylation Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Macromolecule Biosynthetic Process Methylation Cell Cycle Negative Regulation Of Histone Methylation Positive Regulation Of Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Histone Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Histone H3-K4 Methylation Intracellular Signal Transduction
Tagcloud ?		auxin compartments cues distinctive ectopically epidermis hl hydrophilic intercellular localizations localize modular natively pin1 pin2 pin5 pin7 pin8 pins plastic pm polar polarity subcellular switched thaliana trafficking transplanting	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		auxin compartments cues distinctive ectopically epidermis hl hydrophilic intercellular localizations localize modular natively pin1 pin2 pin5 pin7 pin8 pins plastic pm polar polarity subcellular switched thaliana trafficking transplanting	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?