PIN4 and ZBTB9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PIN4	ZBTB9
Description		peptidylprolyl cis/trans isomerase, NIMA-interacting 4	zinc finger and BTB domain containing 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Spindle Cytoskeleton Preribosome	Nucleus
	Molecular Function	DNA Binding Bent DNA Binding Double-stranded DNA Binding RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	RRNA Processing	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Autism spectrum disorder ( 34069769) Rosacea symptom severity ( 29771307)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Lung cancer ( 28604730)
Interacting Genes		19 interacting genes: ASCC2 CEBPA CEP72 CSNK2A1 CSNK2A2 DNM1 EGFR ERBB2 ERBB3 ERBB4 EZH2 FAM9B FATE1 FBL FRMD1 MAGEA11 PNMA1 SPTAN1 ZBTB9	47 interacting genes: CAPN7 CBX8 CDYL2 CHURC1 CIB4 CKS1B DTNB DYRK2 EHHADH EIF4E2 GTF2E1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 LASP1 MCM6 MDFI MORF4L1 MYBL2 NFKB1 NR3C1 PARP1 PIN1 PIN4 PPARG PPARGC1B SNIP1 SYTL4 TCEA2 TCEANC TSPYL1 TSR2 UBE2I ZBTB24 ZBTB26 ZBTB48 ZFP64 ZFY ZKSCAN5 ZNF23 ZNF407 ZNF408 ZNF417 ZNF71 ZZZ3
Entrez ID		5303	221504
HPRD ID		02219	15695
Ensembl ID		ENSG00000102309	ENSG00000213588
Uniprot IDs		Q9Y237	A0A1U9X8U5 Q96C00
PDB IDs		1EQ3 1FJD 3UI4 3UI5 3UI6	9B9V
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB3:ERBB2 Complex ERBB Signaling Pathway Protein Kinase CK2 Complex Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Identical Protein Binding Gland Development Protein Tyrosine Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Regeneration Protein Kinase Activity Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Animal Organ Regeneration Negative Regulation Of Apoptotic Process ERBB2-EGFR Signaling Pathway Negative Regulation Of Programmed Cell Death ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Kinase Activity Protein-containing Complex Localization Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Regulation Of Chromosome Separation Animal Organ Development Regulation Of Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Basolateral Plasma Membrane Positive Regulation Of Growth Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Metabolic Process Liver Development Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Catabolic Process Embryonic Placenta Development	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding DNA Binding Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Intermediate Filament Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Keratin Filament Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Histone H3K27me3 Reader Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Adipose Tissue Development Positive Regulation Of MiRNA Metabolic Process Parental Behavior Nucleoplasm Regulation Of SMAD Protein Signal Transduction DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
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