PIN4 and SPTAN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PIN4	SPTAN1
Gene Name		protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)	spectrin, alpha, non-erythrocytic 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrial Matrix Spindle Preribosome Extracellular Vesicular Exosome	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Bent DNA Binding Double-stranded DNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Poly(A) RNA Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization RRNA Processing	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping
Pathways			Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ASCC2 CEP72 CSNK2A1 CSNK2A2 DNM1 EGFR EZH2 FAM9B FATE1 FBL MAGEA11 PNMA1 SPTAN1 ZBTB9	48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4
Entrez ID		5303	6709
HPRD ID		02219	01684
Ensembl ID		ENSG00000102309	ENSG00000197694
Uniprot IDs		Q9Y237	Q13813
PDB IDs		1EQ3 1FJD 3UI4 3UI5 3UI6	2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Negative Regulation Of Mitotic Cell Cycle Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Negative Regulation Of Protein Catabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Mitotic Cell Cycle Generation Of Neurons Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Neurogenesis Neuron Development Cell Cycle Process Cell Morphogenesis Neuron Differentiation Cell Projection Organization Regulation Of Mitotic Cell Cycle Phase Transition Locomotion Regulation Of Cell Cycle Phase Transition Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Mitotic Cell Cycle Process Cell Cycle Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Cell Differentiation Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Rhythmic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Alkanesulfonate Metabolic Process Histone Glutamine Methylation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Cell Division Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Cell Development Response To External Stimulus	Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus
Tagcloud ?		auxin compartments cues distinctive ectopically epidermis hl hydrophilic intercellular localizations localize modular natively pin1 pin2 pin5 pin7 pin8 pins plastic pm polar polarity subcellular switched thaliana trafficking transplanting	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Difference) ?		auxin compartments cues distinctive ectopically epidermis hl hydrophilic intercellular localizations localize modular natively pin1 pin2 pin5 pin7 pin8 pins plastic pm polar polarity subcellular switched thaliana trafficking transplanting	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Intersection) ?