IK and FRA10AC1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		IK	FRA10AC1
Description		IK cytokine	FRA10A associated CGG repeat 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Cytoplasm Cytoskeleton Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole	Nucleus
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Phosphatase Activity
	Biological Process	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome MRNA Processing Mitotic Spindle Assembly Checkpoint Signaling RNA Splicing Protein Localization To Kinetochore	MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Monocyte count ( 32888494) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 26252872 29274321) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: APP CEBPA CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 FXR1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 OGT PFN2 QARS1 RACK1 RBM10 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10	27 interacting genes: ADPRS C7orf25 CHERP CWC27 EEF1D GATD3 GDPD2 GLRX3 HABP4 IK KASH5 MAP3K12 MFAP1 MOB2 NKAP PLPPR4 PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830
Entrez ID		3550	118924
HPRD ID		02771	12319
Ensembl ID		ENSG00000113141	ENSG00000148690
Uniprot IDs		Q13123 Q95HA6 Q9UK43	Q70Z53
PDB IDs		5O9Z 6Q8I 8QO9 8QZS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus PTB Domain Binding Negative Regulation Of RNA Metabolic Process Chromatin Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Death Regulation Of Programmed Cell Death RNA Binding Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Protein-containing Complex Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process Regulation Of Apoptotic Process Carbohydrate Homeostasis Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Glucose Homeostasis Regulation Of Stem Cell Differentiation NuRD Complex Negative Regulation Of Translation Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing Cellular Response To Carbohydrate Stimulus Positive Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Translation Regulator Activity Intracellular Glucose Homeostasis	RNA Splicing MRNA Processing U2-type Precatalytic Spliceosome MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Nuclear Speck Spliceosomal Complex Nucleic Acid Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Cajal Body Nucleobase-containing Compound Metabolic Process Catalytic Step 2 Spliceosome U2-type Spliceosomal Complex Glycerophosphoinositol Inositolphosphodiesterase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Nucleus Nucleic Acid Binding
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