IK and THOC1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		IK	THOC1
Description		IK cytokine	THO complex subunit 1
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GO Annotations	Cellular Component	Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Cytoplasm Cytoskeleton Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome MRNA Processing Mitotic Spindle Assembly Checkpoint Signaling RNA Splicing Protein Localization To Kinetochore	MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA Transport
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Monocyte count ( 32888494) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Interacting Genes		28 interacting genes: APP CEBPA CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 FXR1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 OGT PFN2 QARS1 RACK1 RBM10 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10	32 interacting genes: AGR2 AKAP9 CTAG1A CTAG1B DHX8 ESS2 EXOC5 EXOSC7 FRA10AC1 GPRASP3 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C PRC1 PRPF6 RABGEF1 RB1 REL SAP30BP SF3B2 SNW1 TADA2A TFIP11 TRIM27 TRIM54 USHBP1 WDR77 ZMYND12
Entrez ID		3550	9984
HPRD ID		02771	09498
Ensembl ID		ENSG00000113141	ENSG00000079134
Uniprot IDs		Q13123 Q95HA6 Q9UK43	Q96FV9
PDB IDs		5O9Z 6Q8I 8QO9 8QZS	1WXP 7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus PTB Domain Binding Negative Regulation Of RNA Metabolic Process Chromatin Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Death Regulation Of Programmed Cell Death RNA Binding Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Protein-containing Complex Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process Regulation Of Apoptotic Process Carbohydrate Homeostasis Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Glucose Homeostasis Regulation Of Stem Cell Differentiation NuRD Complex Negative Regulation Of Translation Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing Cellular Response To Carbohydrate Stimulus Positive Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Translation Regulator Activity Intracellular Glucose Homeostasis	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Spliceosomal Complex RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing Cyclin/CDK Positive Transcription Elongation Factor Complex U2-type Precatalytic Spliceosome
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