PFN1 and LRIF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN1	LRIF1
Gene Name		profilin 1	ligand dependent nuclear receptor interacting factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion Membrane Neuron Projection Synapse Extracellular Vesicular Exosome Blood Microparticle	Nucleus Microtubule Organizing Center Actin Cytoskeleton Nuclear Matrix
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Binding Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Poly(A) RNA Binding Proline-rich Region Binding	Protein Binding Retinoic Acid Receptor Binding
	Biological Process	Neural Tube Closure Platelet Degranulation Blood Coagulation Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Positive Regulation Of DNA Metabolic Process Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Ruffle Assembly	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Signaling by Wnt Platelet activation, signaling and aggregation Signaling by Robo receptor PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: ACTA1 ACTB APBB1IP C14orf1 CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH FMNL1 GPHN LRIF1 MLLT4 MYPOP NCK1 PIK3R1 RAD51 RHOQ SRPK1 STUB1 TLE1 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	129 interactors: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRADD CRCT1 DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 HAP1 HIST3H3 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NHP2L1 NOC2L NR3C1 NRBP1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR2C POLR3F PPARG PQBP1 PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TDGF1 TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSPAN6 UBE2V2 VIM WDR62 WWC1 ZNF24
Entrez ID		5216	55791
HPRD ID		01452	17975
Ensembl ID		ENSG00000108518	ENSG00000121931
Uniprot IDs		P07737	Q5T3J3
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament-based Process Actin Filament Organization Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Membrane Tubulation Response To Stimulus Signaling Actin Polymerization Or Depolymerization Midbrain Development Cytoskeleton Organization Axon Guidance Movement Of Cell Or Subcellular Component Nervous System Development T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Anatomical Structure Development Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Axonogenesis System Development Cell Development Positive Regulation Of Actin Nucleation Neuron Projection Development Cellular Component Assembly Axon Development Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune Response Regulation Of Actin Cytoskeleton Organization Chemotaxis Positive Regulation Of Immune System Process Cell Differentiation Regulation Of Clathrin-mediated Endocytosis Locomotion	Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Protein Metabolic Process System Development Regulation Of Gene Expression Developmental Process Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Multicellular Organismal Development Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Nervous System Development Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Macromolecule Biosynthetic Process Response To Organic Substance Cellular Metabolic Process Response To Stress Positive Regulation Of Apoptotic Process Response To Steroid Hormone Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Regulation Of Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Organic Substance Regulation Of Cell Cycle
Tagcloud ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant	aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate
Tagcloud (Difference) ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant	aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate
Tagcloud (Intersection) ?