PFN1 and XPO6

Number of citations of the paper that reports this interaction (PubMedID 14592989)
61

Data Source:
HPRD (in vitro)

		PFN1	XPO6
Description		profilin 1	exportin 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding Cadherin Binding Proline-rich Region Binding	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Modulation Of Chemical Synaptic Transmission Protein Stabilization Negative Regulation Of Stress Fiber Assembly Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Organization Positive Regulation Of Ruffle Assembly	Protein Export From Nucleus Intracellular Protein Transport Protein Transport
Pathways		Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS		Mean platelet volume ( 32888494)	Apolipoprotein A1 levels ( 32203549) Monocyte count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		34 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN ISG15 LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	7 interacting genes: ACTB DIAPH1 NUP62 PFN1 RNF10 SMAD3 VASP
Entrez ID		5216	23214
HPRD ID		01452	10525
Ensembl ID		ENSG00000108518	ENSG00000169180
Uniprot IDs		P07737	Q96QU8
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW 7P1H 8BJH 8BJI 8BJJ 8BR0 8RTY 9AZP
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Profilin Binding Cytoskeleton Lamellipodium Anchoring Junction Supramolecular Fiber Organization Cytosol Actin Cytoskeleton Focal Adhesion Negative Regulation Of Membrane Tubulation Cytoplasm Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Positive Regulation Of Cellular Component Organization Actin Binding Actin Filament-based Process Positive Regulation Of Filopodium Assembly Regulation Of Cellular Component Organization Protein Localization To Adherens Junction Cell-cell Junction Protein-macromolecule Adaptor Activity SH3 Domain Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Postsynapse Regulation Of Filopodium Assembly Regulation Of Type I Interferon Production Regulation Of Cell Adhesion Regulation Of Protein Localization To Cell Periphery Plasma Membrane Positive Regulation Of Cell Adhesion Apical Protein Localization Adherens Junction Assembly Regulation Of Cell-cell Adhesion Synapse Regulation Of Protein Localization To Membrane Signal Transduction Regulation Of Plasma Membrane Organization Negative Regulation Of Viral Process Ubiquitin-ubiquitin Ligase Activity Protein K63-linked Ubiquitination Protein Polymerization Positive Regulation Of Cell-cell Adhesion Filopodium Cytoskeleton Organization Cell Projection Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Clathrin-dependent Endocytosis Actin Filament	Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Glutamatergic Synapse Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Regulation Of Actin Filament Organization Positive Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Cytoskeleton Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Actin Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Lung Blood Pressure Regulation Of Supramolecular Fiber Organization Nuclear Mineralocorticoid Receptor Binding Regulation Of Actin Filament-based Process Focal Adhesion Actin Filament Positive Regulation Of Protein Polymerization Neural Tube Closure Positive Regulation Of Cellular Component Organization Tube Closure Cell Junction Organization Regulation Of Stress Fiber Assembly Ubiquitin Binding Regulation Of Norepinephrine Uptake Positive Regulation Of Transforming Growth Factor Beta3 Production Blood Microparticle Regulation Of Actin Filament Polymerization Transporter Regulator Activity Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Tube Formation PTB Domain Binding Mitotic Spindle Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Transepithelial Transport Regulation Of Lung Blood Pressure Cytoplasm Negative Regulation Of Cell Differentiation
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