PFN1 and DLG5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid, proximity labelling technology)
HPRD (two hybrid)

		PFN1	DLG5
Description		profilin 1	discs large MAGUK scaffold protein 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Membrane Cell Junction Ciliary Basal Body Cell Projection Synapse Anchoring Junction Glutamatergic Synapse
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding Cadherin Binding Proline-rich Region Binding	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Modulation Of Chemical Synaptic Transmission Protein Stabilization Negative Regulation Of Stress Fiber Assembly Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Organization Positive Regulation Of Ruffle Assembly	Epithelial To Mesenchymal Transition Establishment Or Maintenance Of Cell Polarity Signal Transduction Negative Regulation Of Cell Population Proliferation Tissue Development Positive Regulation Of Signal Transduction Glial Cell Differentiation Maintenance Of Cell Polarity Cell Differentiation Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Animal Organ Development Regulation Of Multicellular Organismal Process Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Neuroepithelial Cell Differentiation Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion Postsynapse Organization
Pathways		Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins	RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs		7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS		Mean platelet volume ( 32888494)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		34 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN ISG15 LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		5216	9231
HPRD ID		01452	04972
Ensembl ID		ENSG00000108518	ENSG00000151208
Uniprot IDs		P07737	Q8TDM6
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW 7P1H 8BJH 8BJI 8BJJ 8BR0 8RTY 9AZP	1UIT
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Profilin Binding Cytoskeleton Lamellipodium Anchoring Junction Supramolecular Fiber Organization Cytosol Actin Cytoskeleton Focal Adhesion Negative Regulation Of Membrane Tubulation Cytoplasm Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Positive Regulation Of Cellular Component Organization Actin Binding Actin Filament-based Process Positive Regulation Of Filopodium Assembly Regulation Of Cellular Component Organization Protein Localization To Adherens Junction Cell-cell Junction Protein-macromolecule Adaptor Activity SH3 Domain Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Postsynapse Regulation Of Filopodium Assembly Regulation Of Type I Interferon Production Regulation Of Cell Adhesion Regulation Of Protein Localization To Cell Periphery Plasma Membrane Positive Regulation Of Cell Adhesion Apical Protein Localization Adherens Junction Assembly Regulation Of Cell-cell Adhesion Synapse Regulation Of Protein Localization To Membrane Signal Transduction Regulation Of Plasma Membrane Organization Negative Regulation Of Viral Process Ubiquitin-ubiquitin Ligase Activity Protein K63-linked Ubiquitination Protein Polymerization Positive Regulation Of Cell-cell Adhesion Filopodium Cytoskeleton Organization Cell Projection Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Clathrin-dependent Endocytosis Actin Filament	Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein-containing Complex Assembly Focal Adhesion Positive Regulation Of Organelle Organization Cellular Response To Lipoprotein Particle Stimulus Basolateral Plasma Membrane Regulation Of Telomere Maintenance Via Telomerase Response To Xenobiotic Stimulus Cholesterol Binding Sphingolipid Floppase Activity Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Dihydrolipoyllysine-residue Succinyltransferase Activity Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Telomere Maintenance Response To Vitamin B3 Regulation Of Cell Communication Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Intracellular Signal Transduction Apolipoprotein A-I Receptor Activity Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Myoblast Fusion Involved In Skeletal Muscle Regeneration Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Renal Inner Medulla Development Scrib-APC-beta-catenin Complex
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