PFN1 and APBB1IP

Number of citations of the paper that reports this interaction (PubMedID 15469846)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PFN1	APBB1IP
Description		profilin 1	amyloid beta precursor protein binding family B member 1 interacting protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium T Cell Receptor Complex Cell Projection Anchoring Junction
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding Cadherin Binding Proline-rich Region Binding	Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Modulation Of Chemical Synaptic Transmission Protein Stabilization Negative Regulation Of Stress Fiber Assembly Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Organization Positive Regulation Of Ruffle Assembly	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Signal Transduction Positive Regulation Of Cell Adhesion
Pathways		Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS		Mean platelet volume ( 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory biomarkers ( 22228203) Lymphocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Response to angiotensin II receptor blocker therapy ( 22566498) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		34 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN ISG15 LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	11 interacting genes: BAG6 EVL GAS7 HRAS NDN PFN1 PRPF40A RAP1A TLX3 VASP ZDHHC17
Entrez ID		5216	54518
HPRD ID		01452	16420
Ensembl ID		ENSG00000108518	ENSG00000077420
Uniprot IDs		P07737	Q7Z5R6
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW 7P1H 8BJH 8BJI 8BJJ 8BR0 8RTY 9AZP	2MWN 3ZDL
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Profilin Binding Cytoskeleton Lamellipodium Anchoring Junction Supramolecular Fiber Organization Cytosol Actin Cytoskeleton Focal Adhesion Negative Regulation Of Membrane Tubulation Cytoplasm Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Positive Regulation Of Cellular Component Organization Actin Binding Actin Filament-based Process Positive Regulation Of Filopodium Assembly Regulation Of Cellular Component Organization Protein Localization To Adherens Junction Cell-cell Junction Protein-macromolecule Adaptor Activity SH3 Domain Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Postsynapse Regulation Of Filopodium Assembly Regulation Of Type I Interferon Production Regulation Of Cell Adhesion Regulation Of Protein Localization To Cell Periphery Plasma Membrane Positive Regulation Of Cell Adhesion Apical Protein Localization Adherens Junction Assembly Regulation Of Cell-cell Adhesion Synapse Regulation Of Protein Localization To Membrane Signal Transduction Regulation Of Plasma Membrane Organization Negative Regulation Of Viral Process Ubiquitin-ubiquitin Ligase Activity Protein K63-linked Ubiquitination Protein Polymerization Positive Regulation Of Cell-cell Adhesion Filopodium Cytoskeleton Organization Cell Projection Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Clathrin-dependent Endocytosis Actin Filament	Regulation Of Ruffle Assembly Developmental Process Positive Regulation Of Actin Filament Polymerization GDP Binding Modulation Of Chemical Synaptic Transmission Profilin Binding Positive Regulation Of Protein Polymerization Glutamatergic Synapse Positive Regulation Of Ruffle Assembly Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Respiratory Gaseous Exchange By Respiratory System Neurotrophin Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Cell Projection Assembly System Development Brain Development Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Small GTPase-mediated Signal Transduction Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Actin Filament Bundle Assembly Protein Homotetramerization Actin Polymerization Or Depolymerization Perforant Pathway To Dendrate Granule Cell Synapse G Protein-coupled Glycine Receptor Activity Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Epithelial Cell Migration G Protein Activity Regulation Of Cell Projection Organization Regulation Of Biological Quality GTPase Complex Response To Antineoplastic Agent Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Postsynaptic Golgi Apparatus
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