PFN1 and APBB1IP

Number of citations of the paper that reports this interaction (PMID 15469846)
97

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PFN1	APBB1IP
Gene Name		profilin 1	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion Membrane Neuron Projection Synapse Extracellular Vesicular Exosome Blood Microparticle	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Binding Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Poly(A) RNA Binding Proline-rich Region Binding	Protein Binding
	Biological Process	Neural Tube Closure Platelet Degranulation Blood Coagulation Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Positive Regulation Of DNA Metabolic Process Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Ruffle Assembly	Signal Transduction Blood Coagulation Platelet Activation
Pathways		Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Signaling by Wnt Platelet activation, signaling and aggregation Signaling by Robo receptor PCP/CE pathway beta-catenin independent WNT signaling	p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS			Inflammatory biomarkers ( 22228203) Response to angiotensin II receptor blocker therapy ( 22566498)
Protein-Protein Interactions		30 interactors: ACTA1 ACTB APBB1IP C14orf1 CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH FMNL1 GPHN LRIF1 MLLT4 MYPOP NCK1 PIK3R1 RAD51 RHOQ SRPK1 STUB1 TLE1 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	8 interactors: EVL GAS7 NDN PFN1 PRPF40A RAP1A VASP ZDHHC17
Entrez ID		5216	54518
HPRD ID		01452	16420
Ensembl ID		ENSG00000108518	ENSG00000077420
Uniprot IDs		P07737	B4E100 Q7Z5R6
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW	3ZDL
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament-based Process Actin Filament Organization Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Membrane Tubulation Response To Stimulus Signaling Actin Polymerization Or Depolymerization Midbrain Development Cytoskeleton Organization Axon Guidance Movement Of Cell Or Subcellular Component Nervous System Development T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Anatomical Structure Development Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Axonogenesis System Development Cell Development Positive Regulation Of Actin Nucleation Neuron Projection Development Cellular Component Assembly Axon Development Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune Response Regulation Of Actin Cytoskeleton Organization Chemotaxis Positive Regulation Of Immune System Process Cell Differentiation Regulation Of Clathrin-mediated Endocytosis Locomotion	Actin Polymerization Or Depolymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Ruffle Assembly Nervous System Development Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Actin Filament-based Process Generation Of Neurons Neurogenesis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Stress Fiber Assembly Actin Filament Organization Cell Part Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cellular Component Biogenesis Cell Development Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Neuron Development Regulation Of Actin Cytoskeleton Organization Regulation Of Stress Fiber Assembly Protein Homotetramerization Cell Morphogenesis Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neuron Differentiation Cell Projection Organization Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Cytoskeleton Organization Protein Tetramerization Neural Tube Closure Axonogenesis System Development Regulation Of Cell Projection Assembly Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neural Tube Formation Response To Growth Factor
Tagcloud ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Difference) ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Intersection) ?