PFN1 and GPHN

Number of citations of the paper that reports this interaction (PubMedID 9473484)
0

Data Source:
HPRD (in vitro)

		PFN1	GPHN
Description		profilin 1	gephyrin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Inhibitory Synapse Synaptic Membrane Glycinergic Synapse Postsynapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component Postsynaptic Specialization
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding Cadherin Binding Proline-rich Region Binding	Nucleotide Binding Catalytic Activity Signaling Receptor Binding Protein Binding ATP Binding Nitrate Reductase Activity Transferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Molybdopterin Cofactor Binding Metal Ion Binding Molecular Adaptor Activity Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Modulation Of Chemical Synaptic Transmission Protein Stabilization Negative Regulation Of Stress Fiber Assembly Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Organization Positive Regulation Of Ruffle Assembly	Mo-molybdopterin Cofactor Biosynthetic Process Synapse Assembly Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdopterin Cofactor Biosynthetic Process Establishment Of Protein Localization Synapse Organization Synaptic Transmission, GABAergic Glycine Receptor Clustering Protein Localization To Membrane Gamma-aminobutyric Acid Receptor Clustering Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins	Molybdenum cofactor biosynthesis
Drugs		7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol	Formic acid Imidazole Propanoic acid
Diseases			Hyperekplexia
GWAS		Mean platelet volume ( 32888494)	Appendicular lean mass ( 33097823) Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		34 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN ISG15 LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	15 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MITD1 MTOR PFN1 PIN1 PSMA1 SPATS1 TUBA4A
Entrez ID		5216	10243
HPRD ID		01452	04893
Ensembl ID		ENSG00000108518	ENSG00000171723
Uniprot IDs		P07737	Q9NQX3
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW 7P1H 8BJH 8BJI 8BJJ 8BR0 8RTY 9AZP	1JLJ
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Profilin Binding Cytoskeleton Lamellipodium Anchoring Junction Supramolecular Fiber Organization Cytosol Actin Cytoskeleton Focal Adhesion Negative Regulation Of Membrane Tubulation Cytoplasm Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Positive Regulation Of Cellular Component Organization Actin Binding Actin Filament-based Process Positive Regulation Of Filopodium Assembly Regulation Of Cellular Component Organization Protein Localization To Adherens Junction Cell-cell Junction Protein-macromolecule Adaptor Activity SH3 Domain Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Postsynapse Regulation Of Filopodium Assembly Regulation Of Type I Interferon Production Regulation Of Cell Adhesion Regulation Of Protein Localization To Cell Periphery Plasma Membrane Positive Regulation Of Cell Adhesion Apical Protein Localization Adherens Junction Assembly Regulation Of Cell-cell Adhesion Synapse Regulation Of Protein Localization To Membrane Signal Transduction Regulation Of Plasma Membrane Organization Negative Regulation Of Viral Process Ubiquitin-ubiquitin Ligase Activity Protein K63-linked Ubiquitination Protein Polymerization Positive Regulation Of Cell-cell Adhesion Filopodium Cytoskeleton Organization Cell Projection Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Clathrin-dependent Endocytosis Actin Filament	GABA-ergic Synapse Microtubule Associated Complex Protein-containing Complex Binding Postsynaptic Specialization Cytoskeleton Organization Microtubule Cytoplasmic Dynein Complex Regulation Of Protein Stability Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Phosphoprotein Binding Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Glycine-gated Chloride Channel Complex Extracellularly Glycine-gated Ion Channel Activity Cis-trans Isomerase Activity Microtubule-based Process Ciliary Tip Dynein Intermediate Chain Binding Dynein Complex Grb2-Sos Complex Myosin V Complex Protein Domain Specific Binding Cytoskeleton Cytosol Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Microtubule Cytoskeleton
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?