PFN1 and GPHN

Number of citations of the paper that reports this interaction (PMID 9473484)
20

Data Source:
HPRD (in vitro)

		PFN1	GPHN
Gene Name		profilin 1	gephyrin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion Membrane Neuron Projection Synapse Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cytoskeleton Plasma Membrane Cell Junction Postsynaptic Membrane Inhibitory Synapse
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Binding Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Poly(A) RNA Binding Proline-rich Region Binding	ATP Binding Transferase Activity Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity
	Biological Process	Neural Tube Closure Platelet Degranulation Blood Coagulation Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Positive Regulation Of DNA Metabolic Process Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Ruffle Assembly	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Small Molecule Metabolic Process Glycine Receptor Clustering
Pathways		Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Signaling by Wnt Platelet activation, signaling and aggregation Signaling by Robo receptor PCP/CE pathway beta-catenin independent WNT signaling	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS			Depression (quantitative trait) ( 23290196)
Protein-Protein Interactions		30 interactors: ACTA1 ACTB APBB1IP C14orf1 CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH FMNL1 GPHN LRIF1 MLLT4 MYPOP NCK1 PIK3R1 RAD51 RHOQ SRPK1 STUB1 TLE1 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	13 interactors: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MTOR PFN1 PIN1 SPATS1 TUBA4A
Entrez ID		5216	10243
HPRD ID		01452	04893
Ensembl ID		ENSG00000108518	ENSG00000171723
Uniprot IDs		P07737	F5H039 F8W7D6 Q9NQX3
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW	1JLJ
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament-based Process Actin Filament Organization Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Membrane Tubulation Response To Stimulus Signaling Actin Polymerization Or Depolymerization Midbrain Development Cytoskeleton Organization Axon Guidance Movement Of Cell Or Subcellular Component Nervous System Development T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Anatomical Structure Development Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Axonogenesis System Development Cell Development Positive Regulation Of Actin Nucleation Neuron Projection Development Cellular Component Assembly Axon Development Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune Response Regulation Of Actin Cytoskeleton Organization Chemotaxis Positive Regulation Of Immune System Process Cell Differentiation Regulation Of Clathrin-mediated Endocytosis Locomotion	Cellular Response To Stimulus Response To Stimulus Signal Transduction Apoptotic Signaling Pathway Signaling G2/M Transition Of Mitotic Cell Cycle Cell Communication Positive Regulation Of Organelle Organization Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Fatty Acid Oxidation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cytoskeleton Organization Cellular Response To Organic Substance Positive Regulation Of Intracellular Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Surface Receptor Signaling Pathway Regulation Of Rho GTPase Activity Positive Regulation Of Mitochondrion Organization Microtubule-based Process Regulation Of Stress Fiber Assembly Regulation Of Carbohydrate Utilization Synaptic Target Recognition Regulation Of Catalytic Activity Regulation Of Rho Protein Signal Transduction Exocytosis Platelet Degranulation Positive Regulation Of Translation Response To Organic Substance Transport Regulation Of Fatty Acid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Mitochondrion Organization Positive Regulation Of RNA Export From Nucleus Apoptotic Process Programmed Cell Death Regulation Of Signal Transduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neural Tube Closure Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Positive Regulation Of Actin Filament Polymerization Cell Death Death
Tagcloud ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant	albeit bcl2 characterizing copy cytogenetic ep300 fl gains hit hodgkin igh illustrate incompletely infrequently insufficient karyotype losses lymphoblastic lymphoma neil1 principally q21 q32 rearrangement specimen transform translocations warrant workup
Tagcloud (Difference) ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant	albeit bcl2 characterizing copy cytogenetic ep300 fl gains hit hodgkin igh illustrate incompletely infrequently insufficient karyotype losses lymphoblastic lymphoma neil1 principally q21 q32 rearrangement specimen transform translocations warrant workup
Tagcloud (Intersection) ?